Article Text

Download PDFPDF
Proximal type epithelioid sarcoma arising in the base of the skull: a diagnostic challenge
  1. Derrick Wen Quan Lian1,
  2. Hwei Yee Lee1,
  3. Kheng Kooi Tan2,
  4. Yih Yian Sitoh3,
  5. Wai Ming Yap1,
  6. Khoon Leong Chuah1
  1. 1Department of Pathology, Tan Tock Seng Hospital, Singapore, Singapore
  2. 2Department of Neurosurgery, National Neuroscience Institute, Singapore, Singapore
  3. 3Department of Neuroradiology, National Neuroscience Institute, Singapore, Singapore
  1. Correspondence to Dr Khoon Leong Chuah, Department of Pathology, Tan Tock Seng Hospital, 11 Jalan, Tan Tock Seng, Singapore 308433, Singapore; gzzckl{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Epithelioid sarcoma (ES) has been described in many sites1 and classical and proximal variants of ES display characteristic loss of INI1 expression.2 We detail, for what is believed to be the first time, a primary ES of the base of skull for which, because of extensive local disease, specific origin from dura or bone3 could not be determined.

A 55-year-old Malay man presented with a 3-month history of epistaxis and visual disturbances. MRI scan revealed a large intracranial extra-axial lobulated mass measuring 7.0×6.1×7.3 cm with extension into the anterior cranial fossa, left posterior choana and left ethmoid sinus, suggesting a meningioma. The patient underwent tumour resection during which part of the skull base and small part of the left frontal lobe were removed. Intra-operatively, the lesion was extra-axial and remote from the normal appearing pituitary gland and suprasellar region. Postoperatively, a thorough physical examination, oesophago-gastro-duodenoscope and CT scan of the thorax, abdomen and pelvis failed to detect a primary tumour elsewhere. A repeat MRI of the brain and spine 1 month post surgery …

View Full Text


  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.