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Letter to the editor
Nerve fibre colonisation by benign glands: word of caution
  1. Walid D Salman,
  2. Ruth Green
  1. East Lancashire Hospitals, UK
  1. Correspondence to Dr W D Salman, Department of Histopathology, Burnley General Hospital, Casterton Avenue, Burnley BB10 2PQ, UK; walid.salman{at}

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Histological diagnosis of malignancy is a constellation of morphological, histochemical, immunohistochemical and even ultrastructural details. Histopathologists rely on a spectrum of morphological features in order to arrive at a diagnosis of malignancy. This includes pleomorphism, mitotic activity, angiolymphatic permeation and perineural infiltration. It came to our attention that the latter phenomenon can be considered evidence of malignancy, but it is in fact nerve fibre colonisation by banal glands. This can result in pathologists making an erroneous …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.