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Snippets in surgical pathology
  1. K Cooper,
  2. R Chetty

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This section features synopses of pertinent practical publications that appear in Pathology journals in the respective sub-specialties. The summaries are mere guidelines and personal opinions of the two authors. The articles selected are diverse but occasionally reflect the authors' bias and are from the more widely read pathology journals. It is not intended to be an assiduous search of every publication in every Pathology journal, but more of a general indication of some of the monthly highlights through the eyes of the authors.

Hopefully, these snippets will provide the reader with enough to glean some facts and tips, as well as encourage them to read the entire article if necessary.

Journal of Clinical Pathology

September 2009

Metias SM, Lianidou E, Yousef GM. MicroRNAs in clinical oncology: at the crossroads between promises and problems. J Clin Pathol 2009;62:771–6.

Very good overview of microRNAs, their involvement in cancer and possible therapeutic applications. Well worth a read.

Llobet D, Pallares J, Yeramian A, et al. Molecular pathology of endometrial carcinoma: practical aspects from the diagnostic and therapeutic viewpoints. J Clin Pathol 2009;62:777–85.

This is an excellent summary of the molecular pathways of endometrial carcinoma. Five molecular features characterise endometrioid carcinomas: microsatellite instability, and mutations in the PTEN, k-RAS, PIK3CA and β-catenin genes; non-endometrioid carcinomas show alterations of p53, loss of heterozygosity on several chromosomes and molecular alterations of STK15, p16, E-cadherin and C-erb B2.

Manduch M, Oliveira AM, Nascimento AG, et al. Massive localised lymphoedema: a clinicopathological study of 22 cases and review of the literature. J Clin Pathol 2009;62:808–11.

An entity occurring in morbidly obese adults with a predilection for the thigh and posterior calf/lower leg. Gross appearance is of markedly thickened skin with a cobblestone appearance. Histologically: dermal fibrosis, thickened fibrous septa with increased stromal fibroblasts, lymphatic proliferation and …

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