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Concurrent occurrence of nodular lymphocyte predominant Hodgkin lymphoma and Kaposi sarcoma in lymph nodes: a first case report
  1. He-Qin Zhan1,2,
  2. Xiao-Qiu Li1,2,
  3. Xiong-Zeng Zhu1,2,
  4. Ye Guo2,3,
  5. Hong-Fen Lu1,2,
  6. Feng Li4
  1. 1Department of Pathology, Fudan University Shanghai Cancer Center, Shanghai, PR China
  2. 2Department of Oncology, Shanghai Medical College, Fudan University, Shanghai, PR China
  3. 3Department of Medical Oncology, Fudan University Shanghai Cancer Center, Shanghai, PR China
  4. 4Department of Pathology, College of Medicine, Shihezi University, Shihezi, PR China
  1. Correspondence to Dr Xiao-Qiu Li, Department of Pathology, Fudan University Shanghai Cancer Center, 270 Dong-An Road, Shanghai 200032, PR China; leexiaoqiu{at}

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Nodular lymphocyte predominant Hodgkin lymphoma (NLPHL) is a rare subtype of Hodgkin lymphoma, which principally affects lymph nodes and is characterised by a nodular, or a nodular and diffuse lymphoid proliferation composed of scattered large neoplastic B cells, namely, L&H cells, in a background of reactive small lymphocytes and accessory cells.1 Kaposi sarcoma (KS) is a locally aggressive endothelial neoplasm that usually involves the skin. Occasionally, KS may involve lymph nodes and other organs, with or without cutaneous lesions.2 We describe herewith an unusual case showing simultaneous presence of NLPHL and KS components as a collision tumour in two lymph nodes of an immunocompetent patient.

The patient, a 31-year-old man, presented with enlarged right inguinal and left supraclavicular lymph nodes without hepatosplenomegaly, skin lesions or systemic symptoms. A CT scan revealed enlarged lymph nodes in his left cervical, bilateral inguinal and pelvic, and retroperitoneal regions. No immune abnormalities were found by the laboratory examination, nor was HIV or Epstein–Barr virus (EBV) infection detected. One lymph node each from the supraclavicular and inguinal region was biopsied. After diagnosis, the patient received six cycles of chemotherapy with adriamycin, bleomycin, vinblastine and dacarbazine (ABVD) regimen and a locoregional radiotherapy (3600cGY/20FX). The patient …

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.