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Evaluation of the clinical efficacy of minimally invasive procedures for breast cancer screening at a teaching hospital
  1. Beatriz Daou Verenhitach1,2,
  2. Simone Elias1,2,
  3. Ana Claudia Patrocínio3,
  4. Afonso Celso Pinto Nazário1,2,
  5. Angela Waizberg4
  1. 1Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil
  2. 2Breast Clinic of the Department of Gynecology, Medical School, Federal University of Sao Paulo, Sao Paulo, Brazil
  3. 3Department of Electrical Engineering, Federal University of Uberlandia, Uberlandia, Minas Gerais, Brazil
  4. 4Department of Pathology, Federal University of Sao Paulo, Sao Paulo, Brazil
  1. Correspondence to Dr Simone Elias, Department of Gynecology, Federal University of Sao Paulo, Sao Paulo, Brazil; simoneelias3{at}


Aims To assess the clinical efficacy of diagnostic procedures for breast cancer at a teaching hospital using internal auditing tools and quality control measures.

Methods A retrospective assessment of 500 patients who underwent core needle biopsy (wide-bore needle biopsy; WBN) of palpable or non-palpable breast nodes that were submitted for at least one cytological examination (fine needle aspiration (FNA) cytology and/or imprint of a WBN specimen). For statistical analysis the auditing tool and quality control proposed by the National Health Service breast screening programme was utilised.

Results For FNA, full specificity, positive predictive value, inadequate rates and suspicious rates were satisfactory while absolute sensitivity, complete sensitivity, false negatives and false positives were unsatisfactory. For imprint, absolute sensitivity, complete sensitivity, inadequate rate from cancers and suspicious rates were satisfactory, and the remaining indicators were unsatisfactory. WBN displayed the best performance with absolute sensitivity, complete sensitivity, false negative, suspicious rates, full specificity and predictive value showing satisfactory results and only one unsatisfactory result (false positive).

Conclusions Based on an overall analysis, WBN displayed the highest clinical efficacy compared with FNA and imprint, and demonstrated adequate safety for confirming the appropriate diagnosis and management of patients, ensuring the efficacy of the service.

  • Audit
  • breast
  • breast cancer

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  • Competing interests None declared.

  • Ethics approval The study was approved by the ethics committee of São Paulo Hospital, Federal University of São Paulo.

  • Provenance peer review Not commissioned; externally peer reviewed.