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A placental chorionic villous mesenchymal core cellular origin for infantile haemangioma
  1. Tinte Itinteang1,2,3,
  2. Swee T Tan1,2,3,4,
  3. Siobhan Guthrie1,
  4. Cherise E S Tan3,
  5. Ben C McIntyre2,3,
  6. Helen D Brasch2,3,5,
  7. Darren J Day1,2,3
  1. 1School of Biological Sciences, Victoria University of Wellington, Wellington, New Zealand
  2. 2Centre for the Study and Treatment of Vascular Birthmarks, Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital, Wellington, New Zealand
  3. 3Gillies McIndoe Research Institute, Wellington, New Zealand
  4. 4Wellington School of Medicine and Health Sciences, University of Otago, Wellington, New Zealand
  5. 5Department of Pathology, Hutt Hospital, Wellington, New Zealand
  1. Correspondence to Professor Swee T Tan, Wellington Regional Plastic, Maxillofacial and Burns Unit, Hutt Hospital, High Street, Private Bag 31-907, Lower Hutt, New Zealand; swee.tan{at}


Aims To investigate the expression of the placental cell-specific associated proteins in infantile haemangioma (IH).

Methods Immunohistochemical staining was used to investigate the expression of human chorionic gonadotrophin (hCG), human placental lactogen (hPL), human leucocyte antigen-G (HLA-G), cytokeratin 7 (CK7) and smooth muscle actin in paraffin-embedded sections of proliferating and involuted IHs.

Results The proteins hCG and hPL were expressed by the endothelium but not the pericyte layer of proliferating IH, but these proteins were not detected in involuted lesions. There was no expression of CK7 and HLA-G in IH.

Conclusions The expression of hCG and hPL, but not CK7 or HLA-G, by the endothelium of proliferating IH supports a placental chorionic villous mesenchymal core cellular origin for IH rather than a trophoblast origin.

  • Apoptosis
  • biological sciences
  • cancer
  • cancer research
  • cell biology
  • chorionic gonadotrophin
  • endothelium
  • head and neck
  • head and neck cancer
  • human
  • immunocytochemistry
  • infantile haemangioma
  • lactogen
  • leucocyte antigen
  • placental chorionic villous mesenchymal core
  • surgical pathology
  • trophoblast
  • tumour angiogenesis
  • tumour biology
  • tumour markers

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  • Swee T Tan and Darren J Day are equal senior authors.

  • Funding This work is supported by grants from the Gillies McIndoe Foundation, Wellington Regional Plastic Surgery Unit Research and Education Trust, and the Victoria University of Wellington Research Trust. Dr Itinteang is supported by the Royal Australasian College of Surgeons' Foundation for Surgery Scholarship.

  • Competing interests None.

  • Ethics approval Ethics approval was obtained from Wellington Regional Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.