Article Text

Download PDFPDF
Evaluation of adjunct immunohistochemistry on reporting patterns of non-small cell lung carcinoma diagnosed histologically in a regional pathology centre
  1. E C McLean,
  2. H Monaghan,
  3. D M Salter,
  4. W A Wallace
  1. Department of Pathology, Royal Infirmary of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr W A Wallace, Department of Pathology, Royal Infirmary of Edinburgh, 51 Little France Crescent, Edinburgh EH 16 4SA, UK; william.wallace{at}


Morphological sub-classification of non-small cell carcinoma in small biopsy specimens presents difficulties for pathologists and recent advances in chemotherapy have resulted in increased pressure to more robustly differentiate between squamous carcinoma and adenocarcinoma. The results of audits examining classification of non-small cell lung carcinoma by pathologists working in a specialist team within a regional centre and the effect of introducing adjunct immunohistochemistry into the reporting pathway are presented. It is concluded that the use of a limited immunohistochemical panel substantially reduces the number of cases when a specific cell type cannot be identified or ‘favoured’ (34% to 6%) and that the classification obtained correlates well with that found in subsequent resection specimens. In addition the introduction of immunohistochemistry substantially reduces the variability in reporting practice between pathologists.

  • Immunophenotyping
  • lung cancer

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests WAW has received sponsorship to attend meetings in the UK and Ireland from Lilly UK.

  • Provenance and peer review Not commissioned; externally peer reviewed.