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Prostatic adenocarcinoma with oncocytic features
  1. Giacomo Fiandrino1,
  2. Marco Lucioni1,
  3. Francesco Filippin1,
  4. Alessandra Viglio1,
  5. Marta Nicola1,
  6. Silvana Molo1,
  7. Vittorio Necchi1,
  8. Houssam Zmerly2,
  9. Sergio Ravasi2,
  10. Marco Paulli1
  1. 1Anatomic Pathology Section, Department of Human Pathology, University of Pavia and Foundation IRCCS Policlinico, San Matteo, Italy
  2. 2Urology Division, Casa di Cura Città di Pavia, Pavia, Italy
  1. Correspondence to Dr Marco Lucioni, Isitituto di Anatomia Patologica, Policlinico San Matteo and University of Pavia, Via Forlanini 14, Pavia 27100, Italy; m.lucioni{at}

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Oncocytic changes define reactive, inflammatory or hyperplastic cellular modifications with cytoplasmic eosinophilia owing to accumulation of mitochondria. The term ‘oncocytic tumour’ is reserved to cases with oncocytes accounting for the entire neoplastic population. Benign and malignant oncocytic tumours are known as oncocytomas and oncocytic carcinomas, respectively. They occur more frequently in kidney and thyroid gland but have also been observed in other organs. In particular, in the prostate they are exceedingly rare, with only three cases described.1–3

Case report

We recently observed a 72-year-old man with a 5-year history of dysuria and prostate enlargement. He did not receive either hormonal therapy or chemotherapy before surgery. Histology after prostatectomy documented adenocarcinoma with oncocytic features, which constituted the entirety of the neoplasm; tumour cells were polygonal and medium-sized with …

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  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.