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Late-onset male hypogonadism: clinical and laboratory evaluation
  1. Clement K M Ho1,
  2. Geoffrey J Beckett2
  1. 1Department of Biochemistry, Raigmore Hospital, Inverness, UK
  2. 2Department of Clinical Biochemistry, Royal Infirmary of Edinburgh, Edinburgh, UK
  1. Correspondence to Dr Clement Ho, Department of Biochemistry, Raigmore Hospital, Old Perth Road, Inverness IV2 3UJ, UK; clement.ho{at}


Late-onset male hypogonadism (LOH) is a clinical and biochemical syndrome associated with advancing age and characterised by low serum testosterone concentrations. An understanding of the physiology of androgens in the ageing man is essential for the appropriate diagnosis of LOH. Clinical assessment of androgen status relevant to clinical biochemists and chemical pathologists is outlined in this review. Laboratory investigations of androgen status in men are not without pitfalls and the authors highlight problems associated with measuring and calculating serum testosterone and its fractions, the interpretation of which can be problematic. Current clinical guidelines and recommendations regarding the diagnosis and monitoring of LOH are also summarised.

  • Ageing
  • endocrinology
  • testis

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  • Competing interests None to declare.

  • Provenance and peer review Commissioned; externally peer reviewed.