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Best practice
HER2 testing in the UK: recommendations for breast and gastric in-situ hybridisation methods
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  1. J M S Bartlett1,2,3,
  2. J Starczynski4,
  3. Neil Atkey5,
  4. E Kay6,
  5. A O'Grady6,
  6. Michael Gandy2,
  7. Merdol Ibrahim2,
  8. Bharat Jasani7,
  9. I O Ellis8,
  10. S E Pinder9,
  11. R A Walker10
  1. 1Endocrine Cancer Group, Edinburgh, UK
  2. 2UK National External Quality Assessment Scheme (UK NEQAS), UCL, London, UK
  3. 3Ontario Institute for Cancer Research, Ontario, Canada
  4. 4Cellular Pathology, Heart of England NHS Foundation Trust, UK
  5. 5Sheffield Diagnostic Genetics Service, Sheffield Children's NHS Foundation Trust, Sheffield, UK
  6. 6Department of Histopathology, Beaumont Hospital, Dublin, Ireland
  7. 7University Hospital of Wales, Cardiff, Wales
  8. 8Department of Pathology, Nottingham, UK
  9. 9Department of Pathology, Kings College Hospital, London, UK
  10. 10Department of Cancer Studies, University of Leicester, Leicester, UK
  1. Correspondence to Professor John M S Bartlett, Ontario Institute for Cancer Research, MaRS Centre, South Tower101 College Street, Suite 800Toronto, Ontario, Canada M5G 0A3; john.bartlett{at}oicr.on.ca

Abstract

These guidelines supplement existing guidelines on HER2 testing by immunohistochemistry and in-situ hybridisation(ISH) methods in the UK. They provide a specific focus on aspects of guidance relevant to HER2 ISH testing methods, both fluorescent and chromogenic. They are formulated to give advice on methodology, interpretation and quality control for ISH-based testing of HER2 status in common tumour types, including both breast and gastric tumours. The aim is to ensure that all ISH-based testing is accurate, reliable and timely.

  • Breast pathology
  • CERB 2
  • fish

https://doi.org/10.1136/jcp.2011.089847

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    Footnotes

    • Funding Support for a writing workshop was provided by Roche Products Ltd, 6 Falcon Way, Shire Park, Welwyn Garden City, Hertfordshire, AL7 1TW.

    • Competing interests None.

    • Provenance and peer review Not commissioned; externally peer reviewed.