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Carcinoid tumour associated with enterovirus infection
  1. John Chia,
  2. Andrew Chia,
  3. Rabiha El-Habbal
  1. EV Med Research, Lomita, California, USA
  1. Correspondence to Dr John K Chia, EV Med Research LLC, 25332 Lomita Avenue #170, Lomita, CA 90717, USA; evmed{at}


Enteroviruses commonly infect the gastrointestinal tract, and replication of enteroviruses has been well documented in the Peyer patches of the small bowel. Chronic enterovirus infection has been found in the stomach and terminal ileum of patients with myalgic encephalomyelitis/chronic fatigue syndrome. The authors report the unexpected finding of enterovirus VP1 protein, by immunoperoxidase staining, in carcinoid tumours found in one patient with myalgic encephalomyelitis/chronic fatigue syndrome and another patient with chronic lower quadrant abdominal pain, and suggest a possible association between enteroviruses and tumorigenesis.

  • Enterovirus
  • carcinoid
  • immunohistochemistry
  • infectious intestinal disease
  • tumour virology
  • virus

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  • Funding EV Med Research.

  • Correction notice This article has been corrected since it was published Online First. It is now a Short report.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Providence Little Company of Mary Hospital.

  • Provenance and peer review Not commissioned; externally peer reviewed.