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Letter to the Editor
Measurement of folate
  1. Robert Leeming
  1. Screening Laboratory, Clinical Chemistry, Children's Hospital, Birmingham, West Midlands, B4 6NH
  1. Correspondence to Dr Robert Leeming, 32 Wootton Green Lane, Balsall Common, Coventry, West Midlands CV7 7EZ, UK; robert{at}

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The measurement of total folate in clinical material became possible with the introduction of the Lactobacillus casei assay some 50 years ago. The use of lactoglobulin as a folate binding agent to measure folate by radioisotope dilution, later fluorimetry, is more user friendly but gives largely similar results.

The principal folate …

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  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.