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Correspondence
Epstein–Barr virus-associated intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration
  1. Ping Xiao1,
  2. Huijuan Shi1,
  3. Huizhong Zhang2,
  4. Fengjiao Meng1,
  5. Jianjun Peng3,
  6. Zunfu Ke1,
  7. Kangwei Wang4,
  8. Yongdong Liu1,
  9. Anjia Han1
  1. 1Department of Pathology, Sun Yat-sen University, The First Affiliated Hospital and Zhongshan School of Medicine, Guangzhou, China
  2. 2Cancer Center, Sun Yat-sen University, Guangzhou, China
  3. 3Department of Surgery, Sun Yat-sen University, The First Affiliated Hospital and Zhongshan School of Medicine, Guangzhou, China
  4. 4Department of Pathology, Guangzhou First Municipal People's Hospital, Guangzhou, China
  1. Correspondence to Anjia Han, Department of Pathology, The First Affiliated Hospital and Zhongshan School of Medicine, Sun Yat-Sen University, 58, Zhongshan Road II, Guangzhou 510080, China; hananjia{at}mail.sysu.edu.cn

https://doi.org/10.1136/jclinpath-2011-200581

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    Introduction

    Lymphoepithelioma-like carcinoma (LELC) of the liver is extremely rare. To our knowledge, only 16 cases of pure LELC or LELC with ordinary adenocarcinoma arising in the hepatobiliary tract have been reported in the English literature.1–7 Most of these tumours (68%, 11/16) were positive for Epstein–Barr virus (EBV) by EBV-encoded small non-polyadenylated RNA (EBER-1) in situ hybridisation.1–6 However, association of intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration with EBV infection has not been reported. We were the first to present two cases of intrahepatic cholangiocarcinoma with dense lymphoplasmacytic infiltration from Southern China, an area that is well known for and has a high-incidence of nasopharyngeal carcinoma, showing EBV infection, but one case of LELC was associated with EBV infection as well.

    Case report

    Clinical features

    After reviewing 207 consecutive cases of intrahepatic cholangiocarcinoma from the Department of Pathology, The First Affiliated Hospital and Cancer Center of Sun Yat-sen University …

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    Footnotes

    • PX and HS equally contributed to this work.

    • Competing interests None.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.