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Lymphoepithelioma-like carcinoma (LELC) of the liver is extremely rare. To our knowledge, only 16 cases of pure LELC or LELC with ordinary adenocarcinoma arising in the hepatobiliary tract have been reported in the English literature.1–7 Most of these tumours (68%, 11/16) were positive for Epstein–Barr virus (EBV) by EBV-encoded small non-polyadenylated RNA (EBER-1) in situ hybridisation.1–6 However, association of intrahepatic cholangiocarcinoma bearing an intense lymphoplasmacytic infiltration with EBV infection has not been reported. We were the first to present two cases of intrahepatic cholangiocarcinoma with dense lymphoplasmacytic infiltration from Southern China, an area that is well known for and has a high-incidence of nasopharyngeal carcinoma, showing EBV infection, but one case of LELC was associated with EBV infection as well.
After reviewing 207 consecutive cases of intrahepatic cholangiocarcinoma from the Department of Pathology, The First Affiliated Hospital and Cancer Center of Sun Yat-sen University …
PX and HS equally contributed to this work.
Competing interests None.
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