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Effect of thrombin receptor expression on microvessel endothelial cells, and survival by coagulation state in oesophageal squamous cell carcinoma
  1. Ying Shao1,
  2. Qin-Qin Xu2,
  3. Chun Li2,
  4. Ming-Yao Wu2,
  5. Xiao-Yan Huang3
  1. 1Women's Hospital School of medicine, Zhejiang University, Hangzhou, Zhejiang, People's Republic of China
  2. 2Department of Pathology, Shantou University Medical College, Shantou, People's Republic of China
  3. 3Cancer Hospital of Shantou University Medical College, Shantou, People's Republic of China
  1. Correspondence to Chun Li, Department of Pathology, Shantou University Medical College, No 22, Xinling Road, Shantou 515041, China; stdx0754{at}


Purpose The authors aimed to evaluate the prognostic value of thrombin receptor (TR) expression in microvessel endothelial cells (VECs) by coagulation state in oesophageal squamous cell carcinoma (ESCC).

Methods In 138 ESCC normal and para-tumour samples, we investigated the association of the expression of TR and CD34 (microvessel marker) seen on immunohistochemical staining and clinicopathological parameters, coagulation state, microvessel density (MVD), and survival of patients.

Result In total, 62 ESCC tissues were positive for TR in VECs, and in 48 cases, the activated partial thromboplastin time (APTT) was <28.5 s, with significant difference in tumour depth between TR-positive and -negative cases with APTT<28.5 s. Also with APTT<28.5 s, TR-positive MVD (TRMVD) was significantly greater with high than low CD34-positive MVD (CD34MVD; 7.96±4.27 vs 5.64±2.99; p=0.032). High CD34MVD was associated with increased TR expression in patients with APTT<28.5 than ≥28.5 s. In patients with high CD34MVD, the number of TR-positive microvessels was greater with APTT<28.5 than ≥28.5 s (n=17 vs n=6; p=0.002), and APTT and TR expressions were negatively correlated for patients with APTT<28.5 s (r2 =−0.472, p=0.023). For patients with APTT<28.5 s, the cumulative survival rate was poorer with high than low TRMVD (p=0.027). On multivariate analysis, tumour size (p=0.006), tumour stage (p=0.004) and TRMVD (p=0.024) were independently associated with survival for patients with APTT<28.5 s. TRMVD had the second highest HR.

Conclusion TR positivity in VECs may be an adverse prognostic factor for patients with ESCC and increased coagulation state. TR expression in VECs might be related to angiogenesis in ESCC.

  • Thrombin receptors
  • oesophageal squamous cell carcinomas
  • prognosis
  • cancer
  • medical statistics
  • surgical pathology

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  • Additional tables are published online only. To view these files please visit the journal online (

  • YS and Q-QX contributed equally to this work.

  • Funding This study was supported by the National Natural Science Foundation of China.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Ethics approval was provided by the Ethical Committee of Cancer Hospital of Shantou City.

  • Provenance and peer review Not commissioned; not externally peer reviewed.