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- infiltrative (infiltrating) epitheliosis
- low-grade adenosquamous carcinoma
- breast cancer
- breast pathology
A 77-year-old woman noted a mass in her right breast, following which she presented to the Asakura Medical Association Hospital (Asakura, Japan). The mass was soft, smooth and round, without lymph node swelling of the axilla, and ∼2.0 cm in size. Her CA19-9 level was slightly high at 39.2 U/ml (normal: <37.0 U/ml). She was involved in a traffic accident 30 years ago. On imaging, mammography showed a regularly shaped mass, while ultrasonography indicated a combination mass with a solid and cystic pattern measuring 2.3×1.1 cm (figure 1). The tumour was therefore considered to be generally benign but solid and had a cystic pattern admixture with unusual ultrasonographic findings. Since malignancy could not be completely excluded, and in accordance with the patient's request, a needle biopsy was performed.
The biopsy specimen showed papillary lesions with abundant stromal proliferations. Under low-power magnification, the nodular lesion appeared to be invasive. On the other hand, under high-power magnification, the luminal cells were cytologically bland and appeared jumbled on top of each other, and some parts indicated possible squamous differentiation. Since there was a suspicion of an invasive process having occurred in the tissue, an additional specimen was requested and an open biopsy was performed.
In the follow-up open biopsy specimen, the mass lesion was vaguely nodular with irregular glands together …
Competing interests None.
Patient consent Obtained.
Ethics approval This study was conducted with the approval of the Asakura Medical Association Hospital Ethical Committee.
Provenance and peer review Not commissioned; externally peer reviewed.