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HPV 18 prevalence in oral mucosa diagnosed with verrucous leukoplakia: cytological and molecular analysis
  1. Julio Cesar Betiol1,
  2. Sérgio Kignel2,
  3. Willys Tristão3,
  4. Ana Carolina Arruda1,
  5. Sabrina Katy Souza Santos1,
  6. Renata Barbieri4,
  7. Jussara de Sousa Ribeiro Bettini1,5
  1. 1NUCISA, Core of Health Sciences, Hermínio Ometto University Center, UNIARARAS, Araras, Brazil
  2. 2Department of Oral Diagnose, Dentistry College, Hermínio Ometto University Center, UNIARARAS, Araras, Brazil
  3. 3Department of Obstetrics and Gynecology, School of Medicine, University of São Paulo—USP, Ribeirão Preto, Brazil
  4. 4Department of Micromorphology, Hermínio Ometto University Center, UNIARARAS, Araras, Brazil
  5. 5Post-Graduation Program in Biomedical Sciences, Hermínio Ometto University Center, UNIARARAS, Araras, Brazil
  1. Correspondence to Julio Cesar Betiol, Av. Dr Maximiliano Baruto, 500 - Jd. Universitário, Araras, SP, Brazil, CEP: 13607-339; julhao_03{at}

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Currently more than 200 types of human papillomaviruses (HPV) have been classified, where the low-risk ones are those that are not capable of developing into cancer while the high-risk ones are.1 Cervical cancer and its preceding lesions have been strongly associated with HPV, mainly through the high-risk 16/18 strains. Due to morphological similarities between the cervical mucosa and the upper aerodigestive tract, it is suggested that HPV be proposed as an aetiological factor in the developing of oral cancer.2

In 1978, WHO defined leukoplakia as a white plaque of oral mucosa, not removable by scraping, which cannot be characterised clinically or pathologically as any other disorder.3 Recent publications have grouped leukoplakia with lesions that precede oral cancer or those that are potentially malignant.4 HPV's role in the aetiology and malignisation of precancerous oral lesions has been studied; however, the results achieved are still not conclusive. The purpose of this study was to identify the prevalence of HPV 16/18 in patients with verrucous leukoplakia of the oral mucosa, along with a profile of their social demographics.


Obtaining samples

The UNIARARAS community, located in Araras, São Paulo, Brazil, was divided in two groups: …

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  • Funding This study was supported by several professors of the NUCISA, and the authors are extremely grateful for the help of the researchers: Dr Camila Andréa de Oliveira, Dr Armindo Antonio Alves from the Programa de Pós Graduação em Ciências Biomédicas do Centro Universitário Hermínio Ometto – UNIARARAS and Dr Ivan Lautenschleguer from the Departamento de Licenciatura em Física do Centro Universitário Hermínio Ometto-UNIARARAS.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval UNIARARAS committee of scientific merit and research ethics under the protocol number 387/2010, decision homologated at the meeting on 8 June 2010.

  • Provenance and peer review Not commissioned; externally peer reviewed.