Article Text

Download PDFPDF
Complex adnexal tumours of the skin: a report of three cases and review of literature
  1. Vanessa London,
  2. Payam Saadat,
  3. Manjunath S Vadmal
  1. Department of Dermatology, University of Southern California-Keck School of Medicine, Los Angeles, California, USA
  1. Correspondence to Dr Manjunath S Vadmal, 6221 Wilshire Blvd. Suite 101 Los Angeles, CA 90048, USA; mvadmal{at}


Aims Complex or composite adnexal tumours of the skin (CATS) are unusual neoplasms composed of two or more histopathologically distinct subtypes of appendageal neoplasms coexisting in a single cutaneous lesion. The authors report three examples of CATS, review literature and discuss their probable histogenesis.

Methods and results Of the three tumours described, one tumour showed a mixture of a proliferating pilar tumour and syringocystadenoma papilliferum, the second lesion was composed of a proliferating pilar tumour and tubulopapillary hidradenoma and the third tumour exhibited a syringocystadenoma papilliferum and tubulopapillary hidradenoma in combination.

Conclusions CATS are rare tumours. The authors reported three unique cases in addition to the 10 other reported cases. These three cases further strengthen the hypothesis of a ‘folliculosebaceous apocrine’ unit as the most likely point of origin of CATS.

  • Skin
  • adnexae
  • complex tumours
  • apocrine
  • pilar
  • proliferating
  • dermatopathology
  • skin tumours
  • surgical pathology
  • tumour biology

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.