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  • Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

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Increased parameters of oxidative stress and its relation to transfusion iron overload in patients with myelodysplastic syndromes

https://doi.org/10.1136/jclinpath-2012-201288

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    Footnotes

    • Funding This work was supported by CAPES, CNPq and FUNCAP.

    • Contributors The following are employees of the laboratory of the Cancer Cytogenetics and Cytogenomics: GFdS, RFP, SMMM. The following are employees of the Department of Clinical and Toxicological Analyses: RPG, TMdJP, MCB, TEdJS. RMdF is a collaborator of the Department of Pharmacy. GFdS has a collection of biological samples from study participants after informed consent, conducted biochemical analyses and wrote the work; she is the guarantor. RFP, SMMM and MMRAM carried out the diagnosis of patients with MDS, interpreted the data and reviewed the manuscript. RPG, TMdJPC and RMdF were responsible for standardisation of techniques of oxidative stress, interpretation of data and reviewed the manuscript. MCB and TEJdS executed measurements of oxidative stress in all participants of the study and conducted statistical analysis.

    • Competing interests None.

    • Ethics approval The study was approved by the local ethics committee (licence 150/2009).

    • Provenance and peer review Not commissioned; externally peer reviewed.