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Periostin expression correlates with pT-stage, grading and tumour size, and independently predicts cancer-specific survival in surgically treated penile squamous cell carcinomas
  1. Sven Gunia1,
  2. Anjun Jain2,
  3. Stefan Koch2,
  4. Stefan Denzinger3,
  5. Stefanie Götz3,
  6. Nina Niessl3,
  7. Matthias May4
  1. 1Institute of Pathology at the Johanniter Hospital Stendal, Germany
  2. 2Institute of Pathology at the HELIOS Clinic Bad Saarow, Charité-University Medicine Academic Teaching Hospital, Bad Saarow, Germany
  3. 3Department of Urology, Regensburg University Clinic St. Josef, Regensburg, Germany
  4. 4Department of Urology, St. Elisabeth Clinic Straubing, Straubing, Germany
  1. Correspondence to Sven Gunia, Department of Pathology Stendal, Institute of Pathology at the Johanniter Hospital Stendal, Straße der Demokratie 1, Stendal 39576, Germany; sven-gunia{at}


Aims Overexpression of periostin, a secreted cell adhesion molecule, has been reported to enhance invasion and angiogenesis in squamous cell carcinomas (SCCs) derived from different anatomic sites. We studied the so far neglected periostin expression profiles in penile SCCs and evaluated its association with pertinent clinicopathologic variables.

Methods Paraffin-embedded tissues from 89 patients with surgically treated penile SCCs were subjected to a central histopathologic review performed by one pathologist. Then, tissue microarray technique was employed for periostin immunostaining which was evaluated by two independent raters. Kappa (κ)-statistics were used to assess interobserver variability. Spearman correlations as well as uni- and multivariable Cox proportional hazards analysis were applied to assess the association between periostin expression and clinicopathologic parameters. Mean postsurgical follow-up was 31.5 months (IQR 6–66).

Results Periostin expression was recorded in 39/89 penile SCCs (44%). K-statistics disclosed substantial interobserver agreement for epithelial and stromal staining evaluation (K-values 0.76 vs 0.83, p values <0.001). High periostin expression in either stroma or tumour epithelia showed a significant positive correlation with tumour size, histologic grade and pT-stage. In the multivariable Cox models including pT-stage, pN status, grading and the patients’ age at the time of surgery, periostin expression independently predicted cancer-specific survival (CSS).

Conclusions Immunohistochemically, periostin is not infrequently expressed in penile cancer, and might become a valuable tool to independently predict CSS after surgical treatment. Further studies should clarify the so far unresolved usefulness of periostin to be employed as a possible molecular target in antineoplastic therapy in metastasised penile SCCs.

  • Penis
  • Immunohistochemistry
  • Carcinoma

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