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Epithelial multinucleated giant cell change in colon polyps
  1. Adriana Handra-Luca1,2
  1. 1Service d'Anatomie pathologique, APHP GHU Avicenne, Bobigny, France
  2. 2Universite Paris Nord Sorbonne Cite, Bobigny, France
  1. Correspondence to Dr Adriana Handra-Luca, Service d'Anatomie pathologique, APHP Hôpital Avicenne Université Paris Nord Sorbonne Cite, 125 rue de Stalingrad, Bobigny 93000, France; adriana.handra-luca{at}

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Multinucleated giant cell change in adenomatous, serrated or hyperplastic polyps is considered as of degenerative nature possibly in relationship to colonoscopy preparation with sodium phosphate, osmotic laxative, as suggested by Lambie and Brown.1 To our knowledge, less than 50 cases of such intestinal polyps have been reported, multiple in five of the reported patients.1–3 Presence of such cellular change in a benign polyp might be relevant for the histological differential diagnosis with virus infection induced atypia or with neoplastic dysplasia.1 ,3 We present two synchronous serrated adenomas with multinucleated giant cell change, located in the right and left colon, and bring new immunohistochemical evidence for the epithelial nature of the multinucleated giant cells.

The colon polyps, one of the right and one of the left colon, had similar microscopic features showing serrated architecture. Several …

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  • Contributors AHL: data analysis, figures, data reporting and writing of the manuscript.

  • Funding None.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.