Article Text

Download PDFPDF
Glomangiomatosis of the sural nerve
  1. Ruple S Laughlin1,
  2. Narupat Suanprasert1,2,
  3. P James B Dyck3,
  4. Robert J Spinner4,
  5. Andrew L Folpe2
  1. 1 Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
  2. 2 Department of Neurology, Prasat Neurological Institute, Bangkok, Thailand
  3. 3 Peripheral Neuropathy Research Laboratory, Department of Neurology, Mayo Clinic, Rochester, Minnesota, USA
  4. 4 Department of Neurosurgery, Mayo Clinic, Rochester, Minnesota, USA
  5. 5 Department of Laboratory Medicine and Pathology, Mayo Clinic, Rochester, Minnesota, USA
  1. Correspondence to Professor Andrew L Folpe, Department of Laboratory Medicine and Pathology, Mayo Clinic, 200 1st Street SW, Rochester, MN 55905, USA; Folpe.Andrew{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Glomus tumours are rare soft tissue tumours that originate from (or differentiate along the lines of) the normal glomus body. Although the normal glomus body is found exclusively in the skin and coccygeal region (glomus coccygeum), glomus tumours have been reported in a wide variety of soft tissue and visceral locations.1 ,2 Intraneural glomus tumours, however, are quite rare, with only 10 previously reported cases (reviewed in3 ,4).

WHO currently classifies glomus tumours as (1) typical glomus tumours, (2) glomovenous malformations (glomangiomas), (3) symplastic glomus tumours, (4) malignant glomus tumours and (5) glomangiomatosis.1 Glomangiomatosis is the least common variant of glomus tumour and consists of an infiltrative proliferation of abnormally configured blood vessels resembling angiomatosis (diffuse haemangioma),5 with nests of glomus cells investing the vessel walls.1 ,6 To date, only a very small number of cases of glomangiomatosis have been reported (reviewed in7); none have involved the peripheral nerve. Herein, we report a 56-year-old man with glomangiomatosis involving the sural nerve.

Tissue obtained from the biopsy of the right sural nerve was routinely processed and H&E and periodic acid Schiff’s with diastase digestion (PAS-D) stains were performed. Immunohistochemistry for smooth muscle actin was performed on formalin-fixed tissue, using our standard laboratory protocols.

A 56-year-old man developed sudden onset of …

View Full Text


  • Contributors All of the authors have contributed to the writing and editing of this manuscript. In addition, NS, PJBD and ALF were involved in the initial evaluation of the pathology specimen, and RSL and RJS in the evaluation of the patient. RSL and ALF prepared the figures. ALF is responsible for the overall content as a guarantor.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Mayo Clinic Institutional Review Board.

  • Provenance and peer review Not commissioned; internally peer reviewed.