Article Text

Download PDFPDF
The value of archival tissue blocks in understanding breast cancer biology
  1. Thomas Dowsett,
  2. Eldo Verghese,
  3. Steven Pollock,
  4. Jennifer Pollard,
  5. Judith Heads,
  6. Andrew Hanby,
  7. Valerie Speirs
  1. Leeds Institute of Cancer and Pathology, University of Leeds, Leeds, UK
  1. Correspondence to Professor Valerie Speirs, Leeds Institute of Cancer and Pathology, Wellcome Trust Brenner Building, St James's University Hospital, Leeds LS9 7TF, UK; v.speirs{at}


Pathological reporting of breast cancer has evolved alongside scientific advances. Such advances have led to recognition of different molecular classes of breast cancer resulting in improved disease management. The aim of this study was to establish whether these advances could be applied to archival breast cancer cases dating from the 1940s to assess historical trends. Important observations included the marked differences in pathological reporting, size of tumour and in ERα expression throughout the decades.


Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.