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Primary extranodal marginal zone B cell lymphoma of the uterus: a case study and review of the literature
  1. Anita J Merritt1,
  2. Patrick Shenjere2,
  3. Lia P Menasce2,
  4. Fiona Reid3,
  5. Tim Diss4,
  6. Rhona J McVey1,
  7. Richard J Byers1,5
  1. 1Department of Histopathology, Manchester Royal Infirmary, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
  2. 2Department of Histopathology, The Christie NHS Foundation Trust, Manchester, UK
  3. 3Department of Gynaecology, St Marys Hospital, Central Manchester University Hospitals NHS Foundation Trust, Manchester, UK
  4. 4Department of Pathology, UCL-Advanced Diagnostics, University College London, London, UK
  5. 5Institute of Cancer Sciences, The University of Manchester, Manchester, UK
  1. Correspondence to Dr Richard Byers, Department of Histopathology, Clinical Sciences Building One, Manchester Royal Infirmary, Oxford Road, Manchester M13 9WL, UK; r.byers{at} and richard.byers{at}

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Extranodal non-Hodgkin's lymphoma (NHL) within the female genital tract is unusual, accounting for 1.5% of extranodal NHL, mostly in the ovaries. Primary NHLs of the uterus and cervix are rare, comprising only 0.54%–0.64% of all extranodal NHLs, most occurring in the cervix.1 Marginal zone lymphoma of mucosa-associated lymphoid tissue (MALT) of the uterus is extremely rare, with only seven cases reported in the literature.2–8 We report a rare case of an extranodal marginal zone B cell lymphoma arising from the MALT tissue of the endometrium.

A 77-year-old woman presented with utero-vaginal prolapse, urinary frequency and nocturia; she had no B symptoms. Examination revealed a cystocoele and a cervical prolapse. There was no palpable lymphadenopathy or hepatosplenomegally and she underwent vaginal hysterectomy and pelvic floor repair. The uterus and cervix measured 8.3×2.6×2.2 cm. The endometrium was 0.2 cm thick and the myometrium 1.6 cm thick; both appeared normal. Microscopically, the endometrium and superficial myometrium contained a nodular infiltrate of monotonous, small to medium-sized, lymphoid cells (figure 1A). The cells …

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  • Contributors AJM wrote the manuscript. PS, LPM, RJMcV and RJB made the diagnosis and wrote the manuscript. FR provided clinical liaison and treated the patient. TD undertook scientific analysis detailed in the case report.

  • Competing interests None.

  • Patients Consent Obtained.

  • Provenance and peer review Not commissioned; internally peer reviewed.