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Overexpression of integrin αv correlates with poor prognosis in colorectal cancer
  1. Sang Yun Ha1,
  2. Juyoun Shin2,
  3. Jeong Hoon Kim3,4,
  4. Myung Soo Kang3,4,
  5. Hae-Yong Yoo3,4,
  6. Hyeon-Ho Kim3,4,
  7. Sung-Hee Um5,
  8. Seok-Hyung Kim1,3,4
  1. 1Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine, Seoul, Korea
  2. 2Division of Cancer Biology, Comparative Biomedicine Research Branch, Research Institute of National Cancer Center, Goyang, Korea
  3. 3Samsung Biomedical Research Institute, Samsung Medical Center, Seoul, Korea
  4. 4Department of Health Sciences and Technology, Sungkyunkwan University School of Medicine, Seoul, Korea
  5. 5Department of Cell Biology, Sungkyunkwan University School of Medicine, Suwon, Korea
  1. Correspondence to Professor Seok-Hyung Kim, Department of Pathology, Samsung Medical Center, Sungkyunkwan University School of Medicine 50 Irwon-dong, Gangnam-gu, Seoul 135-710, Korea; platoshkim{at}


Aims Integrin αv subunits are involved in tumour angiogenesis and tumour progression in various types of cancers. Clinical trials evaluating agents targeting integrin αv are ongoing. Integrin αv expression has been reported in several cancers in association with tumour progression or poor survival. However, no study has addressed the prognostic influence of integrin αv expression on survival of patients with colorectal cancer (CRC).

Methods Immunohistochemical staining of integrin αv was performed in 198 CRC samples to evaluate its prognostic significance.

Results High expression of integrin αv was observed in 58.1% (115/189) of colorectal adenocarcinoma samples, while only in 11.5% (3/26) of tubular adenoma samples and in none of normal mucosa or hyperplastic polyp samples. It was more frequently found in female patients and less frequently observed in well differentiated tumours. The proportion of cases with high expression of integrin αv showed an increasing trend with increased T stage (p=0.032), N stage (p=0.006) and TNM stage (p=0.001). Patients displaying exuberant expression of integrin αv showed shorter overall survival (p=0.001) and disease-free survival (p=0.004). Elevated integrin αv expression was an independent prognostic factor for overall survival (HR: 2.04, 95% CI 1.16 to 3.56; p=0.013) and disease-free survival (HR: 2.19, 95% CI 1.16 to 4.13; p=0.015).

Conclusions Overexpression of integrin αv is associated with advanced T and N stage and as an independent prognostic factor in CRC.

  • Cancer
  • Colorectal Cancer
  • cell-adhesion molecules

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