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Training in molecular pathology during residency: the experience of a Brazilian hospital
  1. Mariana Petaccia de Macedo1,
  2. Louise D Brot Andrade1,
  3. Victor Piana Andrade1,
  4. José Vassallo1,
  5. Antonio Hugo J F M Campos1,2,
  6. Clóvis Antônio Lopes Pinto1,
  7. Cynthia Aparecida Bueno Toledo de Osório1,
  8. Maria Dirlei Ferreira de Souza Begnami1,
  9. Dirce Maria Carraro2,3,
  10. Fernando Augusto Soares1,
  11. Isabela Werneck da Cunha1
  1. 1 Department of Pathology, AC Camargo Cancer Center, São Paulo, Brazil
  2. 2 A C Camargo Biobank, AC Camargo Cancer Center, São Paulo, Brazil
  3. 3 Laboratory of Genomics and Molecular Biology, CIPE, AC Camargo Cancer Center, São Paulo, Brazil
  1. Correspondence to Dr Mariana Petaccia de Macedo, Department of Pathology, AC Camargo Cancer Center, Rua Antonio Prudente, 211, Liberdade, São Paulo 01509-010, Brazil; maripetaccia{at}

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We have read with great interest the recent publication ‘Integrating molecular diagnostics into histopathology training: the Belfast model’ by Flynn et al.1 We would like to contribute this discussion by presenting a model that we introduced at AC Camargo Cancer Center several years ago.

Molecular pathology (MP) and its application in making diagnoses, prognoses and in developing therapeutics are significant with regard to the scientific community and patient care, being an area in which pathology residents must be trained properly.2 Much knowledge has been accumulated in recent years in this field3—some of which remains far from reaching clinical practice; nevertheless, many findings have been applied toward patient care. Clinical applications will increase the demand of knowledge in MP rapidly, representing a major challenge for pathology training programmes.

Goals for MP education have been established, comprising the acquisition of basic concepts in molecular biology; familiarisation with basic technologies and instrumentation; an understanding of the requirements for specimen for molecular tests; knowledge in interpreting test results; clinical application of molecular tests; knowledge on how to search the scientific literature; skills in laboratory management; quality control; and the legal, ethical and social implications of such tests.4 ,5

The Federal Ministry of Education regulates medical residency programmes in Brazil. The pathology programme is a 3-year programme that begins after 6 years of medical school and covers anatomic pathology exclusively. Laboratory medicine is a different programme. According to Brazilian guidelines for pathology residency, first-year residents should …

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  • Funding We acknowledge Fundação de Amparo á Pesquisa do Estado de São Paulo (FAPESP, grant 2011/08510-2) for financial support.

  • Contributors CALP, CABTdO, LDBA, MDFdSB, DMC analysed the data and MPdM, VPA, JV, AHJFMC, FAS and IWdC wrote the manuscript.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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