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Peritoneal dissemination of a gastric API2-MALT1-positive MALT lymphoma
  1. Christian Krautz1,
  2. Friederike Kuithan2,
  3. Jakob Dobroschke1,
  4. Inga Nagel3,
  5. Sylvia Hartmann4,
  6. Daniela E Aust2,
  7. Gustavo Baretton2,
  8. Juergen Weitz1,
  9. Christoph Reissfelder1
  1. 1 Department of Visceral, Thoracic and Vascular Surgery, Technische Universität Dresden, Dresden, Germany
  2. 2 Department of Pathology, Technische Universität Dresden, Dresden, Germany
  3. 3 Institute of Human Genetics, Christian-Albrechts-Universität & Universitätskrankenhaus Schleswig-Holstein, Campus Kiel, Germany
  4. 4 Dr. Senckenberg Institute of Pathology, Goethe Universität, Frankfurt am Main, Germany
  1. Correspondence to Christian Krautz, Department of Visceral, Thoracic and Vascular Surgery, Technische Universität Dresden, Fetscherstrasse 74, Dresden 01307, Germany; christian.krautz{at}

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The majority of mucosa-associated lymphoid tissue (MALT) lymphomas arises in the stomach but a variety of extranodal sites inside or outside the gastrointestinal (GI) tract can be afflicted.1 Gastric MALT lymphomas most frequently spread to a GI site, MALT lymphomas of extragastric origin rather disseminate to a non-GI site. Moreover, gastric MALT lymphomas disseminate less frequently (up to 25%) than extragastric MALT lymphomas (up to 46%).2 It has been reported that at diagnosis up to a third of all MALT lymphomas have disseminated with involvement of one or multiple MALT-containing organs or non-MALT-containing organs.1 The lymph nodes, bone marrow, spleen and liver are common non-MALT sites but also dissemination to the pleura has been described.3 However, involvement of the peritoneum has not been reported before.

Case presentation

A patient with an unremarkable social and family history was referred to us for therapy of a newly diagnosed rectal tumour suspicious for cancer. Staging confirmed a large, obstructing tumour of the middle rectum, which showed high-grade dysplasia and atypical glands suspicious for invasive cancer on histological examination (category 4.3 of the revised Vienna classification). Although, signs of locoregional lymph node metastases were missing, we found multiple small mesenteric lesions and ascites in addition to a thickening of the entire stomach wall (figure 1A) and suspiciously enlarged retrocrural and upper abdominal lymph nodes on a CT scan. Subsequent oesophagogastroduodenoscopy revealed multiple peptic …

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  • Contributors CK, JD, CR and JW contributed to patient management and drafted the report. IN carried out the fluorescence in situ hybridisation studies and helped to draft the report. FK, DEA, SH and GB performed the molecular genetic studies and pathological examination and helped to draft the report. All authors read and approved the final manuscript.

  • Competing interests None.

  • Provenance and peer review Not commissioned; externally peer reviewed.