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Correspondence
Array-based comparative genomic hybridisation analysis of a pleomorphic myxoid liposarcoma
  1. David Creytens1,
  2. Joost van Gorp2,
  3. Liesbeth Ferdinande1,
  4. Nadine Van Roy3,
  5. Louis Libbrecht1
  1. 1Department of Pathology, Ghent University and Ghent University Hospital, Ghent, Belgium
  2. 2Department of Pathology, Diakonessenhuis Utrecht, Utrecht, The Netherlands
  3. 3Department of Medical Genetics, Ghent University, Ghent University Hospital, Ghent, Belgium
  1. Correspondence to Dr David Creytens, Department of Pathology, Ghent University Hospital, De Pintelaan 185, Ghent 9000, Belgium; david.creytens{at}uzgent.be, creytensdavid{at}hotmail.com

https://doi.org/10.1136/jclinpath-2014-202420

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    Pleomorphic myxoid liposarcoma, first described and defined by Alaggio et al1 ,2 as a neoplasm showing mixed distinctive histological features of conventional myxoid liposarcoma and pleomorphic liposarcoma and usually occurring in young patients, is a very rare and still poorly explored and under-recognised tumour entity. Boland et al3 reported an additional series of these lesions in the mediastinum of young patients with morphological features of a pleomorphic liposarcoma with prominent myxoid changes composed of areas resembling myxoid liposarcoma juxtaposed to myxoid areas containing bizarre pleomorphic lipoblasts. At present, it is still unclear whether this sarcoma represents a high-grade variant of a myxoid liposarcoma, a distinct morphologic myxoid variant of a conventional pleomorphic liposarcoma or an unique form of liposarcoma.

    We report the case of a 21-year-old male who presented with a large mass with a maximal diameter of 16 cm arising in the neck. Histology of the resection revealed a myxoid, infiltrative growing tumour consisting of a homogeneous myxoid matrix containing ‘lymphangioma-like’ myxoid pools, a delicate plexiform capillary network and scattered lipoblasts (figure 1 …

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    Footnotes

    • Contributors All of the authors have contributed to the writing and editing of this manuscript. DC, JvG, LF and LL reviewed and reported upon the histopathological and molecular FISH findings. NVR performed the array-based genomic hybridisation analysis.

    • Competing interests None.

    • Patient consent Obtained.

    • Ethics approval Ghent University Hospital.

    • Provenance and peer review Not commissioned; externally peer reviewed.