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Chronic diverticulitis and Crohn's disease share the same expression of basic fibroblastic growth factor, syndecan 1 and tumour necrosis factor-α
  1. Antonio Tursi1,
  2. Walter Elisei2,
  3. Cosimo Damiano Inchingolo3,
  4. Rosanna Nenna3,
  5. Marcello Picchio4,
  6. Enzo Ierardi5,
  7. Giovanni Brandimarte6
  1. 1 Gastroenterology Service, ASL BAT, Andria (BT), Italy
  2. 2 Division of Gastroenterology, ASL Roma H, Albano Laziale (Roma), Italy
  3. 3 Division of Pathology, “Lorenzo Bonomo” Hospital, ASL BAT, Andria (BT), Italy
  4. 4 Division of Surgery, “Paolo Colombo” Hospital, ASL Roma H, Velletri (Roma), Italy
  5. 5 Department of Medical Sciences, Section of Gastroenterology, University of Foggia, Foggia, Italy
  6. 6 Division of Gastroenterology, “Cristo Re” Hospital, Roma, Italy
  1. Correspondence to Dr Antonio Tursi, Servizio di Gastroenterologia Territoriale, ASL BAT, Via Torino, 49, Andria, BT 76123, Italy; antotursi{at}

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It is well known that complicated diverticular disease (DD), which includes Acute Uncomplicated Diverticulitis (AUD), Acute Complicated Diverticulitis (ACD) and Chronic Diverticulitis (CDiv), is characterised by profound structural changes in the colonic tissue, varying from tissue disruption to fibrosis; it has been hypothesised that an unbalanced expression of matrix metalloproteinases (MMP) and their inhibitors (TIMP) protein expression in the bowel wall might, at least in part, mediate this process.1 However, there is limited knowledge about the role of MMPs in the pathogenesis of diverticulitis. It has been reported that altered concentrations of MMPs and TIMPs may explain the structural changes found in diverticulitis.1 Crohn's disease (CD) is a chronic inflammatory disorder of the gastrointestinal tract characterised by chronic, multifocal transmural inflammation potentially affecting the whole gastrointestinal tract, particularly in the ileocolonic segment. Altadill et al 2 recently hypothesised that CD and complicated DD seem to share the same destiny: a chronic inflammation evolving towards fibrosis.

Adhesion molecules containing heparan sulfate (syndecan family) are proteo-glycans, and play a significant role in tissue repair.3 Basic fibroblast growth factor (bFGF) is a peptide able to …

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  • Contributors Study conception and design: AT. Acquisition of data: AT, WE, CDI, RN, EI and GB. Analysis and interpretation of data: AT, WE and MP. Writing manuscript: AT.

  • Competing interests None.

  • Patient consent Obtained.

  • Ethics approval Institutional Review Board of “Cristo Re” Hospital.

  • Provenance and peer review Not commissioned; internally peer reviewed.