Article Text

Download PDFPDF
Prevalence of human papillomavirus in squamous cell carcinomas of the soft palate
  1. Vibe Lyng Frandsen,
  2. Christian Grønhøj Larsen,
  3. Christian von Buchwald
  1. Department of Oto-rhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark
  1. Correspondence to Dr Christian Grønhøj Larsen, Department of Oto-rhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark; c.gronhoj{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

Oral and pharyngeal cancers are the sixth most common cancer and account for up to 4% of all tumours worldwide.1 Human papillomavirus (HPV) is an established aetiological factor for oropharyngeal squamous cell carcinoma (OPSCC),2 and HPV-positive OPSCCs show distinct tumour biology and pathological characteristics, improved treatment responses and survival compared with HPV-negative OPSCCs.2 ,3 Several biomarkers for presence of HPV infection exist, including oncoproteins, serological markers and HPV DNA.4 The biomarker p16 is broadly used as a surrogate marker for HPV infection and staining greater than 70% seems to correlate with the presence of transcriptionally active HPV.5 The overall HPV prevalence in tonsillar SCC is 58% in a newly published Danish study but reduced involvement of …

View Full Text


  • VLF and CGL share first authorship.

  • Contributors VLF searched the scientific literature and extracted data. All authors provided conceptual input, interpreted the findings, and contributed in significant ways to the final article.

  • Funding CGL is funded by the non-profit Candys Foundation and Kræftfonden (The Cancer Foundation).

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.