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Correspondence
Prevalence of human papillomavirus in squamous cell carcinomas of the soft palate
  1. Vibe Lyng Frandsen,
  2. Christian Grønhøj Larsen,
  3. Christian von Buchwald
  1. Department of Oto-rhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Copenhagen, Denmark
  1. Correspondence to Dr Christian Grønhøj Larsen, Department of Oto-rhinolaryngology, Head and Neck Surgery and Audiology, Rigshospitalet, Blegdamsvej 9, Copenhagen 2100, Denmark; c.gronhoj{at}gmail.com

https://doi.org/10.1136/jclinpath-2015-203081

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    Oral and pharyngeal cancers are the sixth most common cancer and account for up to 4% of all tumours worldwide.1 Human papillomavirus (HPV) is an established aetiological factor for oropharyngeal squamous cell carcinoma (OPSCC),2 and HPV-positive OPSCCs show distinct tumour biology and pathological characteristics, improved treatment responses and survival compared with HPV-negative OPSCCs.2 ,3 Several biomarkers for presence of HPV infection exist, including oncoproteins, serological markers and HPV DNA.4 The biomarker p16 is broadly used as a surrogate marker for HPV infection and staining greater than 70% seems to correlate with the presence of transcriptionally active HPV.5 The overall HPV prevalence in tonsillar SCC is 58% in a newly published Danish study but reduced involvement of …

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    Footnotes

    • VLF and CGL share first authorship.

    • Contributors VLF searched the scientific literature and extracted data. All authors provided conceptual input, interpreted the findings, and contributed in significant ways to the final article.

    • Funding CGL is funded by the non-profit Candys Foundation and Kræftfonden (The Cancer Foundation).

    • Competing interests None declared.

    • Provenance and peer review Not commissioned; externally peer reviewed.