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HPV infection status in cervical metaplastic carcinomas
  1. Yiming Luo1,
  2. Qian Yao1,
  3. Caixia Ren2,
  4. Xue Ding1,
  5. Ajin Hu1,
  6. Congrong Liu1
  1. 1Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, Beijing, China
  2. 2Department of Histology and Embryology, Peking University Health Science Center, Beijing, China
  1. Correspondence to Dr Congrong Liu, Department of Pathology, School of Basic Medical Sciences, Third Hospital, Peking University Health Science Center, 38 College Road, Haidian, Beijing 100191, China; congrong_liu{at}

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Cervical metaplastic carcinomas, including most cases of malignant mixed müllerian tumours (MMMTs), or carcinosarcomas, and sarcomatoid carcinomas, are rare biphasic neoplasms.1 ,2 Recent research suggests that both elements share a common epithelial origin, with sarcomatous/sarcomatoid component derived from a metaplastic process.3 We report a series of three cases, one cervical MMMT and two cervical sarcomatoid carcinomas, with their clinicopathological features, immunohistochemical profile and human papillomavirus (HPV) infection status and genotype. Materials and methods are provided in online supplementary appendix 1.

Case report

Clinical history and sequence of events

Case 1 was a 45-year-old woman, gravida 2, para 1 (G2P1), who presented with abnormal vaginal bleeding for 6 months. On pelvic examination, a cauliflower-like cervical mass was found. Biopsy and subsequent investigations showed stage IB2 homologous MMMT. The patient underwent neoadjuvant chemotherapy. Then total abdominal hysterectomy, bilateral salpingo-oophorectomy (TAH-BSO) with pelvic and para-aortic lymphadenectomy was performed, followed by concurrent chemoradiotherapy. Six months later, metastatic lesions were found in the vaginal stump, bladder and rectum. Because of poor response to subsequent chemoradiotherapy, she gave up further treatment.

Case 2 was a 38-year-old woman, G2P1, who presented with abnormal vaginal bleeding for 3 years. Pelvic examination showed a cervical exophytic mass. Biopsy showed squamous cell carcinoma. The patient then underwent TAH-BSO with pelvic lymphadenectomy. Final pathology confirmed stage IB1 cervical sarcomatoid carcinoma. The patient then received radiochemotherapy and remained disease-free for >5 years.

Case 3 was a 61-year-old woman, G2P1, who presented for abnormal pap smear. Pelvic examination …

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  • YL and QY contributed equally.

  • Contributors YL, QY, CR, XD, AH and CL contributed to the development and submission of this manuscript as follows: designing the study, directing its implementation and writing the discussion section; pathological review and immunohistochemical study; experiments on HPV status and genotype; conducting the literature review; preparing the materials and methods and case study sections; supervising the entire research activities and revising it critically for important intellectual content.

  • Funding National Natural Science Foundation of China (grant no. 81472430).

  • Competing interests None.

  • Patient consent Obtained.

  • Provenance and peer review Not commissioned; externally peer reviewed.