Figure 1

Figure 1

Clinical features of Cushing's syndrome. The overt presentation is clinically unmistakable (central ‘truncal’ obesity, ‘moon facies’ and ‘buffalo humps’), milder cases are more difficult to diagnose, due to the wide spectrum of manifestations. None of its symptoms are pathognomonic and many of its features are commonly seen in the general population. Clinical signs that have been reported to best discriminate Cushing's syndrome from obesity include easy bruising, skin atrophy, unexplained osteoporosis, proximal muscle weakness, reddish purple striae and facial plethora.