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A comparison of the pathological, clinical and radiographical, features of cryptogenic organising pneumonia, acute fibrinous and organising pneumonia and granulomatous organising pneumonia
  1. Marc B Feinstein1,
  2. Shilpa A DeSouza1,
  3. Andre L Moreira2,
  4. Diane E Stover1,
  5. Robert T Heelan3,
  6. Tunç A Iyriboz3,
  7. Ying Taur1,
  8. William D Travis2
  1. 1Department of Medicine, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
  2. 2Department of Pathology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
  3. 3Department of Radiology, Memorial Sloan-Kettering Cancer Center, New York, New York, USA
  1. Correspondence to Dr Marc B Feinstein, Pulmonary Division, Memorial Sloan-Kettering Cancer Center, 1275 York Avenue, New York, NY 10065, USA; feinstem{at}


Aims Cryptogenic organising pneumonia (COP) and acute fibrinous and organising pneumonia (AFOP) are recognised patterns of organising pneumonia (OP), a condition that resembles pneumonia but is not caused by infection. We have recognised granulomatous organising pneumonia (GOP) to be a similar histopathological entity where non-necrotising granulomata are intimately associated with the organising connective tissue. To what degree COP, AFOP and GOP represent distinct clinical and pathological disorders is unknown. This cross-sectional study sought to compare the pathological, clinical, and radiographical features of these OP patterns.

Methods Surgical lung biopsy specimens were reviewed for consecutive patients referred with OP to a metropolitan cancer centre. Clinical information and CT images were acquired from the hospital electronic medical record to determine the clinical and CT characteristics of each OP pattern.

Results Sixty-one patients (35 men, 26 women), mean age 61.5 years (range 8–85 years), were available for analysis. Of these, 43 patients (70%) had at least one prior cancer; 27 (44%) had received chemotherapy and 18 (30%) had received radiation. Approximately, half (32 patients) had respiratory symptoms, most commonly cough, dyspnoea and/or wheezing. While symptoms and mortality rates were not different among OP groups, AFOP patients more commonly had fever (p=0.04). GOP patients less commonly had received chemotherapy (p=0.03) and were more likely to present as masses/nodules (p=0.04).

Conclusions AFOP and GOP, a newly described OP form, possess clinical and pathological findings that set it apart from a COP, suggesting an emerging spectrum of OP.

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