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  • ALK positive large B-cell lymphoma with a massive neutrophilic infiltrate: report of a case mimicking epithelioid inflammatory myofibroblastic tumour

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ALK positive large B-cell lymphoma with a massive neutrophilic infiltrate: report of a case mimicking epithelioid inflammatory myofibroblastic tumour
  1. Shih-Yao Lin1,
  2. Shih-Sung Chuang2,
  3. Jie-Yang Jhuang1,
  4. Kana Sakamoto3,
  5. Kengo Takeuchi3,
  6. Armita Bahrami4,
  7. Chien-Chen Tsai1
  1. 1Department of Anatomical Pathology, Far Eastern Memorial Hospital, New Taipei City, Taiwan
  2. 2Department of Pathology and Taipei Medical University, Chi-Mei Medical Centre, Tainan, Taiwan
  3. 3Pathology Project for Molecular Targets of the Cancer Institute/Division of Pathology of the Cancer Institute Hospital, Japanese Foundation for Cancer Research, Tokyo, Japan
  4. 4Department of Pathology, St. Jude Children's Research Hospital, Memphis, Tennessee, USA
  1. Correspondence to Dr Chien-Chen Tsai, Department of Anatomical Pathology, Far Eastern Memorial Hospital, No.21, Sec. 2, Nanya S. Rd., Banciao Dist., New Taipei City 220, Taiwan; a0970295250{at}gmail.com

https://doi.org/10.1136/jclinpath-2014-202847

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    Anaplastic lymphoma kinase (ALK)-positive large B-cell lymphoma (ALK+LBCL) is a rare, distinct and aggressive entity defined as a neoplasm of ALK-positive monomorphic large immunoblastic-like B cells.1 The tumour cells are considered to be derived from post-germinal centre B cells with plasmablastic differentiation and frequently show a cytoplasmic granular pattern of ALK.1 Nodal (most commonly to be cervical nodes) and extranodal presentation (including bone, head and neck, liver and spleen, gastrointestinal tract) have been reported.2 Here we reported a case of intestinal ALK+LBCL with systemic involvement mimicking the epithelioid variant of inflammatory myofibroblastic tumour (epiIMT).

    A 46-year-old woman presented in March 2014 with repeated episodes of melaena for 1 month associated with general weakness, vomiting, body weight loss and pitting oedema of bilateral lower limbs. At the Emergency Department, ileus and anaemia (haemoglobin at 6.4 g/dL) were noted, and chest X-ray revealed a mass in the right lower lobe of lung. CT scans of chest and abdomen showed a 7 cm tumour in the right lower lobe of lung, a 3 cm nodule in the abdominal wall and a 12 cm polypoid tumour in the jejunum with adhesion to sigmoid colon (figure 1). She underwent resection of the tumours in the jejunum and abdominal wall. The upper jejunal tumour was located 40 cm distal to Treitz ligament with adhesion to the sigmoid …

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    Footnotes

    • Correction notice This article has been corrected since it was published Online First. The provenance and peer review statement has been amended.

    • Contributors S-SC, KS, KT and AB: Performed the experiments and analysed the data. S-SC, J-YJ, KT, AB and C-CT: Examined the case and made the final diagnosis. S-YL, S-SC and C-CT: Wrote the manuscript. All authors approved the manuscript.

    • Competing interests None.

    • Ethics approval Research Ethics Review Committee of the Far Eastern Memorial Hospital, Taiwan.

    • Provenance and peer review Not commissioned; externally peer reviewed.