You are here

Article Text

Article menu
Download PDFPDF
PostScript
Correspondence
Preanalytical ammonia generation: a race with time but not with temperature
  1. Peter Schuff-Werner,
  2. Michael Steiner
  1. Correspondence to Dr Peter Schuff-Werner, Institute of Clinical Chemistry and Laboratory Medicine, Rostock University Medical Center, Ernst-Heydemann-Straße 6, Rostock D-18057, Germany; pschuffw{at}gmail.com

https://doi.org/10.1136/jclinpath-2015-203080

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    As recently published by Dukic and Simundic1 in this journal, measurement of reliable ammonia is a real challenge in clinical chemistry. This was brought to the point by Burtis et al (1994) in Tietz Textbook of Clinical Chemistry using the following statement: ‘The key to reliable values from ammonia assays is control of sources of preanalytical error’.2

    In this context, the authors discuss that correct ammonia values depend—beside other critical preanalytical conditions—on the activity of γ-glutamyl-transferase (GGT) by hydrolysing glutamine.3

    This might be a problem in patients with advanced liver disease due …

    View Full Text

    Footnotes

    • Contributors The conception of the work, acquisition of the material, analysis and interpretation of data were completed by PS-W and MS.

    • Competing interests None declared.

    • Patient consent Obtained.

    • Provenance and peer review Not commissioned; externally peer reviewed.