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AGXT2L1 is down-regulated in heptocellular carcinoma and associated with abnormal lipogenesis
  1. Qianshan Ding1,
  2. Jian Kang1,
  3. Jinfen Dai1,
  4. Meng Tang2,
  5. Qi Wang3,
  6. Haotian Zhang4,
  7. Wenyi Guo5,
  8. Rongze Sun5,
  9. Honggang Yu1
  1. 1Department of Gastroenterology, Renmin Hospital of Wuhan University, Wuhan, China
  2. 2Department of Immunology, School of Basic Medicine, Wuhan University, Wuhan, China
  3. 3Department of Oncology, Renmin Hospital of Wuhan University, Wuhan, China
  4. 4Department of Math and Statistics, Liberal Arts College, Portland State University, Portland, OR, USA
  5. 5Department of Hepatobiliary and Laparoscopic Surgery, Renmin Hospital of Wuhan University, Wuhan, China
  1. Correspondence to Dr Yu Honggang, Department of Gastroenterology, Renmin Hospital of Wuhan University, Institute for Gastroenterology and Hepatology, Wuhan University, Jiefang Road 238, Wuhan 430060, Hubei Province, China; yhg_rmhwh{at}


Aims To clarify the clinical implications and functional role of the alanine-glyoxylate aminotransferase 2-like 1 (AGXT2L1) gene in hepatocellular carcinoma (HCC).

Methods and results We confirmed that AGXT2L1 was down-regulated in liver cancer samples by immunohistochemical (IHC) staining. We also demonstrated that this down-regulation was associated with several clinicopathological features such as alpha fetoprotein (AFP) serum level and T stage. Furthermore, we showed with Kaplan-Meier analysis that expression of AGXT2L1 in tumour samples was significantly correlated with patient prognosis. The bioinformatic tool indicated that AGXT2L1 plays a role in the lipid metabolic process of HCC tissue, while siRNA silenced the expression of AGXT2L1 in HCC 97H and LM3 cells, confirming that down-regulation of AGXT2L1 promotes the lipogenesis of cancer cells.

Conclusions For the first time, we have shown that AGXT2L1 is down-regulated in HCC and its low expression indicates a poor prognosis. Our findings also demonstrated that AGXT2L1 is a crucial gene in the abnormal lipogenesis of HCC tissue.


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