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Detection of Epstein–Barr virus in different sources of materials from patients with oral lichen planus: a case–control study
  1. Rúbia da Rocha Vieira1,
  2. Lígia Lavezo Ferreira1,
  3. Éder Ricardo Biasoli1,
  4. Daniel Galera Bernabé1,
  5. Cáris Maroni Nunes2,
  6. Glauco Issamu Miyahara1
  1. 1Oral Oncology Center and Department of Pathology and Clinical Propaedeutics, Araçatuba School of Dentistry, Araçatuba, São Paulo, Brazil
  2. 2Animal Health and Production, Araçatuba School of Veterinary Medicine, Araçatuba, São Paulo, Brazil
  1. Correspondence to Glauco Issamu Miyahara: Oral Oncology Center Araçatuba Dentistry School, Univ Estadual Paulista José Bonifácio street, 1.193 zip code 16015-050 - Araçatuba, São Paulo State, Brazil;


Aims To detect the presence of Epstein–Barr virus (EBV) DNA in different sources of materials from a matched group of patients with oral lichen planus (OLP) and a group of people without OLP lesions, and to correlate the presence of virus with epidemiological variables of the groups studied.

Methods Fresh tissue samples, saliva, exfoliated cells and plasma of 24 patients with OLP lesions (cases) and 17 patients without OLP lesions (controls) were collected. EBV was detected by nested PCR.

Results Viral positivity was obtained in 62.5% of tissue samples; in 70.8% of exfoliated cell samples; in 33.3% of blood plasma samples and in 75% of saliva samples in the cases; and in 35.3% of tissue samples; 82.4% of exfoliated cell samples; in 47.1% of blood plasma samples and in 64.7% of saliva samples in the controls. There was a predominance of women in both groups. Variables not atrophic-erosive were most affected by EBV.

Conclusions No relationship between EBV and OLP was found. However, all sources tested in this study were considered suitable for the detection of viruses.

  • EBV

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