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Evaluation of anticoagulant effects of direct thrombin inhibitors, dabigatran and argatroban, based on the Lineweaver–Burk plot applied to the Clauss assay

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  • Contributors YF and MW equally contributed to this work. MW conceived the study. YF, MW, HK and NS designed the study. YF and KO performed the experiments. YF and MW analysed the data. YF, MW, HK and MM participated in the discussion. YF and MW wrote the manuscript. All authors have given final approval for this version of the manuscript to be published.

  • Funding This work was supported by the JSPS Grant-in-Aid for Scientific Research (A) (research project number 23249030) for MM and by the Keio Gijuku Academic Development Funds for HK.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.