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Genetic mutations in accordance with a low malignant potential tumour are not demonstrated in clear cell papillary renal cell carcinoma
  1. Maria Rosaria Raspollini1,
  2. Francesca Castiglione1,
  3. Liang Cheng2,
  4. Rodolfo Montironi3,
  5. Antonio Lopez-Beltran4,5
  1. 1Department of Histopathology and Molecular Diagnostics, University Hospital Careggi, Florence, Italy
  2. 2Department of Pathology and Laboratory Medicine, Indiana University School of Medicine, Indianapolis, Indiana, USA
  3. 3Section of Pathological Anatomy, Department of Biomedical Sciences and Public Health Polytechnic University of the Marche Region, School of Medicine, United Hospitals, Ancona, Italy
  4. 4Unit of Anatomic Pathology, Department of Surgery, Cordoba University Medical School, Cordoba, Spain
  5. 5Champalimaud Clinical Center, Lisbon, Portugal
  1. Correspondence to Dr Maria Rosaria Raspollini, Department of Histopathology and Molecular Diagnostics, University Hospital Careggi, Largo Brambilla, 3, Florence 50134, Italy; mariarosaria.raspollini{at}


Clear cell papillary renal cell carcinoma (CCPRCC) cases were evaluated for mutations on the following genes: KRAS, NRAS, BRAF, PIK3CA, ALK, ERBB2, DDR2, MAP2K1, RET and EGFR. Four male and three female patients of age 42–74 years were evaluated. All cases were incidentally detected by ultrasound and ranged 1.8–3.5 cm. Microscopic examination showed variably tubulopapillary, tubular acinar, cystic architecture and the characteristic linear arrangement of nuclei. The cells were reactive with CK7 (strong), CA IX (cup-shape) and 34 β E12. CD10, AMACR/RACEMASE and GATA3 were negative. There were no mutations on any of the investigated genes. This preliminary observation supports the concept that CCPRCC might be indeed an indolent tumour worth it to be named as clear cell papillary neoplasm of low potential.


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