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Hypoxia-inducible factor 1α predicts recurrence in high-grade soft tissue sarcoma of extremities and trunk wall
  1. H Nyström1,
  2. M Jönsson2,
  3. L Werner-Hartman2,
  4. M Nilbert2,3,
  5. A Carneiro1
  1. 1 Lund University, Skåne University Hospital, Department of Clinical Sciences Lund, Oncology, Lund, Sweden
  2. 2 Lund University, Faculty of Medicine, Department of Clinical Sciences Lund, Oncology, Lund, Sweden
  3. 3 Clinical Research Centre, Hvidovre Hospital, Copenhagen University, Hvidovre, Denmark
  1. Correspondence to Dr Helena NyströmDivision of Oncology, Institute of Clinical Sciences, Skane University Hospital, Lund 221 85, Sweden; Helena.Nystrom{at}med.lu.se

Footnotes

  • Handling editor Cheok Soon Lee.

  • Contributors AC, MN and HN were responsible for study design. HN, AC, MN and MJ performed immunohistochemical evaluations. HN, LW-H, AC and MN were involved in data analysis and interpretation of data. HN, AC and MN were responsible for drafting the manuscript. MJ and LW-H revised the manuscript critically for important intellectual content.

  • Funding This study was financially supported by the Swedish Cancer Fund, the ALF Funds at Lund University, the Nilsson Cancer Fund and the Kamprad Cancer Fund. Immunohistochemical stainings for CD16, CD163, CSF-1 were kindly performed by I Espinosa, Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain and M Van de Rijn, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

  • Competing interests None declared.

  • Ethics approval Lund Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • Handling editor Cheok Soon Lee.

  • Contributors AC, MN and HN were responsible for study design. HN, AC, MN and MJ performed immunohistochemical evaluations. HN, LW-H, AC and MN were involved in data analysis and interpretation of data. HN, AC and MN were responsible for drafting the manuscript. MJ and LW-H revised the manuscript critically for important intellectual content.

  • Funding This study was financially supported by the Swedish Cancer Fund, the ALF Funds at Lund University, the Nilsson Cancer Fund and the Kamprad Cancer Fund. Immunohistochemical stainings for CD16, CD163, CSF-1 were kindly performed by I Espinosa, Department of Pathology, Hospital de la Santa Creu i Sant Pau, Autonomous University of Barcelona, Barcelona, Spain and M Van de Rijn, Department of Pathology, Stanford University School of Medicine, Stanford, California, USA

  • Competing interests None declared.

  • Ethics approval Lund Ethics Committee.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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