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Original article
Reduced angiomotin p130 expression correlates with poor prognosis in lung adenocarcinoma
  1. Si-Hyong Jang1,
  2. Hyun Deuk Cho1,
  3. Ji-Hye Lee1,
  4. Hyun Ju Lee1,
  5. Soon Auck Hong1,
  6. Junhun Cho1,
  7. Han Jo Kim2,
  8. Mee-Hye Oh1
  1. 1Department of Pathology, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea
  2. 2Department of Internal Medicine, Soonchunhyang University Cheonan Hospital, College of Medicine, Soonchunhyang University, Cheonan, Korea
  1. Correspondence to Dr Mee-Hye Oh, Department of Pathology, Soonchunhyang University Cheonan Hospital, 31, Soonchunhyang 6 Gil, Dongnam-gu, Cheonan 330-721, Korea; mhoh0212{at}hanmail.net

Abstract

Aims Lung cancer is the leading cause of cancer-related deaths worldwide, and it still results in a poor prognosis despite research and development of a treatment modality. Angiomotin (AMOT) was first described as a protein involved in angiogenesis, and although the oncogenic and tumour-suppressive roles of AMOT were recently reported, the biological function of AMOT has not yet been clarified. The aim of this study was thus to evaluate the relationship between reduced AMOT p130 expression and clinicopathological parameters, including patients' survival.

Methods We enrolled 67 patients with lung adenocarcinoma in this study and measured the immunoreactivity of AMOT p130 in a tissue microarray. The data were analysed using a χ2 test, Cox regression hazards model and log-rank test with Kaplan–Meier curves.

Results Reduced AMOT p130 expression is related to lung adenocarcinoma developed at a young age with statistical significance, but there is no statistical significance for the other clinicopathological parameters. Kaplan–Meier curves with log-rank test showed that reduced AMOT p130 expression had significantly better survival rate compared with the retained group (p=0.002). Univariable and multivariable analyses of the disease free survival revealed that the decreased AMOT expression was an independent prognostic factor (p=0.004, p=0.008, respectively).

Conclusions Decreased AMOT p130 could be an independent indicator of poor survival in patients with lung adenocarcinoma.

  • LUNG CANCER
  • IMMUNOHISTOCHEMISTRY
  • TUMOUR MARKERS

https://doi.org/10.1136/jclinpath-2016-204071

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    Footnotes

    • S-HJ and HDC contributed equally.

    • Handling editor Cheok Soon Lee

    • Contributors S-HJ drafted this manuscript. M-HO established conception and design of this study. S-HJ, HDC and M-HO performed pathological evaluation. HDC and HJK collected and arranged clinicopathological data. JHC and HDC performed statistical analysis. SAH, JHL and HJL reviewed the literature and helped to draft this manuscript. MHO finally approved the submission of this article.

    • Funding This work was supported in part by Soonchunhyang University Research Fund.

    • Competing interests None declared.

    • Ethics approval Institution review board of Soonchunhyang University Cheonan Hospital.

    • Provenance and peer review Not commissioned; externally peer reviewed.