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TRKA expression and NTRK1 gene copy number across solid tumours
  1. Gianluca Mauri1,2,
  2. Emanuele Valtorta1,3,
  3. Giulio Cerea1,
  4. Alessio Amatu1,
  5. Michele Schirru1,
  6. Giovanna Marrapese1,
  7. Vincenzo Fiorillo1,3,
  8. Patrizia Recchimuzzo1,3,
  9. Ivana Stella Cavenago1,3,
  10. Erica Francesca Bonazzina1,
  11. Valentina Motta1,3,
  12. Calogero Lauricella1,3,
  13. Silvio Veronese1,3,
  14. Federica Tosi1,2,
  15. Martina Maiolani1,2,
  16. Giuseppe Rospo4,
  17. Mauro Truini1,3,
  18. Emanuela Bonoldi1,3,
  19. Jason Christiansen5,
  20. Steven J Potts5,
  21. Salvatore Siena1,2,
  22. Andrea Sartore-Bianchi1,2
  1. 1 Niguarda Cancer Center, Grande Ospedale Metropolitano Niguarda, Milan, Italy
  2. 2 Dipartimento di Ematologia e Onco-Ematologia, Università degli Studi di Milano, Milan, Italy
  3. 3 Department of Laboratory Medicine, Division of Pathology, Grande Ospedale Metropolitano Niguarda, Milan, Italy
  4. 4 Candiolo Cancer Institute–FPO, IRCCS, Turin, Italy
  5. 5 Ignyta Inc, San Diego, California, USA
  1. Correspondence to Dr Andrea Sartore-Bianchi, Niguarda Cancer Center, Università degli Studi di Milano, Milano, 20162, Italy; andrea.sartorebianchi{at}ospedaleniguarda.it

Footnotes

  • GM and EV contributed equally.

  • Handling editor Runjan Chetty.

  • Contributors GMau and EV: acquisition, analysis and interpretation of data for the study; writing the study; final approval of the version to be published. GC, MS, GMar, VF, PR, ISC, EFB, VM, CL, FT and MM: acquisition, analysis and interpretation of data for the study; final approval of the version to be published. AA: acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published. SV, MT, EB, JC, SJP: acquisition, analysis and interpretation of data for the study; revising critically the study; final approval of the version to be published. GR: analysis and interpretation of data for the study; final approval of the version to be published. SS: acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published. AS-B: conception and design of the study; acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published.

  • Funding The molecular screening for NTRK1 was performed within the phase I ALKA-001 clinical trial funded by Ignyta, Inc. The study was partly supported by the grant ‘Terapia Molecolare dei Tumori’ by Fondazione Oncologia Niguarda; Associazione Italiana Ricerca Cancro grant AIRC 5 x mille Project ID 51000 Special Program Molecular Clinical Oncology; AIRC Investigator Grant Project ID 20685; AIRC 5 x mille project ID Project 21091; CORDIS Community Research and Development Information Service, grant MoTriColor, Horizon 2020 Project ID 635342.

  • Competing interests SS is a member of the Advisory Boards for Bayer and Ignyta; AS-B is a member of the Advisory Boards for Bayer. All other authors have no competing interest to declare.

  • Patient consent Obtained.

  • Ethics approval Ethical Committee of Grande Ospedale Metropolitano Niguarda.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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Footnotes

  • GM and EV contributed equally.

  • Handling editor Runjan Chetty.

  • Contributors GMau and EV: acquisition, analysis and interpretation of data for the study; writing the study; final approval of the version to be published. GC, MS, GMar, VF, PR, ISC, EFB, VM, CL, FT and MM: acquisition, analysis and interpretation of data for the study; final approval of the version to be published. AA: acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published. SV, MT, EB, JC, SJP: acquisition, analysis and interpretation of data for the study; revising critically the study; final approval of the version to be published. GR: analysis and interpretation of data for the study; final approval of the version to be published. SS: acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published. AS-B: conception and design of the study; acquisition, analysis and interpretation of data for the study; writing the study; revising critically the study; final approval of the version to be published.

  • Funding The molecular screening for NTRK1 was performed within the phase I ALKA-001 clinical trial funded by Ignyta, Inc. The study was partly supported by the grant ‘Terapia Molecolare dei Tumori’ by Fondazione Oncologia Niguarda; Associazione Italiana Ricerca Cancro grant AIRC 5 x mille Project ID 51000 Special Program Molecular Clinical Oncology; AIRC Investigator Grant Project ID 20685; AIRC 5 x mille project ID Project 21091; CORDIS Community Research and Development Information Service, grant MoTriColor, Horizon 2020 Project ID 635342.

  • Competing interests SS is a member of the Advisory Boards for Bayer and Ignyta; AS-B is a member of the Advisory Boards for Bayer. All other authors have no competing interest to declare.

  • Patient consent Obtained.

  • Ethics approval Ethical Committee of Grande Ospedale Metropolitano Niguarda.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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