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Assessment of peritoneal elastic laminal invasion improves survival stratification of pT3 and pT4a colorectal cancer: a meta-analysis
  1. Toru Odate,
  2. Huy Gia Vuong,
  3. Kunio Mochizuki,
  4. Naoki Oishi,
  5. Tetsuo Kondo
  1. Department of Pathology, University of Yamanashi, Yamanashi, Japan
  1. Correspondence to Dr Tetsuo Kondo, Department of Pathology, University of Yamanashi, Yamanashi 409-3898, Japan; ktetsuo{at}yamanashi.ac.jp

Abstract

Evaluating peritoneal elastic laminal invasion (ELI) has been proposed as an additional assessment for pT3 colorectal cancers (CRC). Its clinical significance has not yet been established. We performed a meta-analysis to investigate the prognostic impact of ELI assessment for subcategorisation of pT3 CRC. We performed a search in three electronic databases. HR and its 95% CI for overall survival (OS) and disease-free survival (DFS) were calculated using the random effects model weighted by the inverse variance method. We identified six studies that met inclusion criteria out of an original 703 studies found with our database search terms. Our meta-analysis included 1925 patients with pT3 and pT4a CRCs. The presence of ELI in pT3 CRC was associated with shortened OS compared with ELI negative pT3 CRC (HR=1.76; 95% CI 1.21 to 2.55); whereas the DFS was not statistically significant (HR=1.79; 95% CI 0.91 to 3.52). Furthermore, pT4a patients’ OS (HR=1.84; 95% CI 1.41 to 2.40) and DFS (HR=1.88; 95% CI 1.17 to 3.04) were even worse than the OS and DFS of pT3 ELI (+) patients. ELI is a useful marker for stratifying patients with pT3 or pT4a CRCs into three prognostically distinct groups. We recommend the subcategorisation of pT3 CRC by ELI for better prognostic assessment and treatment strategy of patients with CRC.

  • colorectal cancer
  • elastic laminal invasion
  • elastic staining
  • serosal invasion
  • meta-analysis
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Footnotes

  • Handling editor Runjan Chetty.

  • TO and HGV contributed equally.

  • Contributors All authors have contributed in this manuscript preparation and agreed for this submission.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

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