You are here

Article Text

Article menu
Download PDFPDF
Best practice
Disorders of phosphate metabolism
  1. Jenny Leung,
  2. Martin Crook
  1. Clinical Biochemistry, University Hospital Lewisham, London, UK
  1. Correspondence to Professor Martin Crook, University Hospital Lewisham, clinical biochemistry, London SE136LH, UK; martin.crook{at}doctors.org.uk

Abstract

Phosphate in both inorganic and organic form is essential for several functions in the body. Plasma phosphate level is maintained by a complex interaction between intestinal absorption, renal tubular reabsorption, and the transcellular movement of phosphate between intracellular fluid and bone storage pools. This homeostasis is regulated by several hormones, principally the parathyroid hormone, 1,25-dihydroxyvitamin D and fibroblast growth factor 23. Abnormalities in phosphate regulation can lead to serious and fatal complications. In this review phosphate homeostasis and the aetiology, pathophysiology, clinical features, investigation and management of hypophosphataemia and hyperphosphataemia will be discussed.

  • hypophosphataemia
  • hyperphosphataemia
  • phosphate
  • refeeding syndrome

https://doi.org/10.1136/jclinpath-2018-205130

Statistics from Altmetric.com

    Request Permissions

    If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.

    View Full Text

    Footnotes

    • Handling editor Tahir S Pillay.

    • Contributors Both authors contributed to the review article.

    • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

    • Competing interests None declared.

    • Patient consent for publication Not required.

    • Provenance and peer review Commissioned; internally peer reviewed.