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Positive association of PIK3CA mutation with KRAS mutation but not BRAF mutation in colorectal cancer suggests co-selection is gene specific but not pathway specific

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  • Handling editor Runjan Chetty.

  • Contributors SS, WF, MI: conception or design of the work. SS, WF, SM, JCH, HOE: data collection. SS, WF, SM: data analysis and interpretation. SS, MI: drafting the article. AO, MI: critical revision of the article. All: final approval of the version to be published.

  • Funding This study was funded by EC Marie Curie Actions, AIDPATH project (Contract No. 612471) and Nottingham Molecular Pathology Node (NMPN) MR/N005953/1.

  • Competing interests None declared.

  • Patient consent Not required.

  • Ethics approval Nottingham Health Sciences Biobank which has approval as an IRB from North West—Greater Manchester Central Research Ethics Committee REC reference: 15/NW/0685 and Tissue Governance NHS Lothian under ethics approval number SR783.

  • Provenance and peer review Not commissioned; externally peer reviewed.