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Transformation of marginal zone lymphoma (MZL) to aggressive lymphoma is considered a rare event with most cases evolving into diffuse large B-cell lymphoma (DLBCL).1 Here, we present a case of splenic MZL (sMZL) transforming into classic Hodgkin lymphoma (cHL).
A patient, with a history of IgD-positive sMZL and treated with several cycles of rituximab and bendamustine and radiotherapy of the spleen, presented 2 years after initial diagnosis with bone pain due to osteolysis of the Os ilium. An imaging-guided bone biopsy revealed infiltrates of cHL (figure 1) while the patient still had residual histologically documented sMZL in the spleen …
Handling editor Mary Frances McMullin.
Provenance and peer review Not commissioned; externally peer reviewed.