Article Text

Download PDFPDF
Transformation of a splenic marginal zone lymphoma into classic Hodgkin lymphoma
  1. Thomas Menter,
  2. Stefan Dirnhofer,
  3. Alexandar Tzankov
  1. Institute of Pathology, University Hospital Basel, Basel, Switzerland
  1. Correspondence to Professor Alexandar Tzankov, Institute of Pathology, University Hospital Basel, Basel 4031, Switzerland; alexandar.tzankov{at}

Statistics from

Request Permissions

If you wish to reuse any or all of this article please use the link below which will take you to the Copyright Clearance Center’s RightsLink service. You will be able to get a quick price and instant permission to reuse the content in many different ways.


Transformation of marginal zone lymphoma (MZL) to aggressive lymphoma is considered a rare event with most cases evolving into diffuse large B-cell lymphoma (DLBCL).1 Here, we present a case of splenic MZL (sMZL) transforming into classic Hodgkin lymphoma (cHL).

A patient, with a history of IgD-positive sMZL and treated with several cycles of rituximab and bendamustine and radiotherapy of the spleen, presented 2 years after initial diagnosis with bone pain due to osteolysis of the Os ilium. An imaging-guided bone biopsy revealed infiltrates of cHL (figure 1) while the patient still had residual histologically documented sMZL in the spleen …

View Full Text


  • Handling editor Mary Frances McMullin.

  • Provenance and peer review Not commissioned; externally peer reviewed.