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Clinicopathological characteristics of ypT0N0 urothelial carcinoma following neoadjuvant chemotherapy and cystectomy
  1. Martin J Magers1,
  2. Hristos Z Kaimakliotis2,
  3. Marcelo P Barboza2,
  4. Elhaam Bandali2,
  5. Nabil Adra3,
  6. Michael O Koch2,
  7. Liang Cheng1,2
  1. 1 Department of Pathology, Indiana University School of Medicine, Indianapolis, Indiana, USA
  2. 2 Department of Urology, Indiana University School of Medicine, Indianapolis, Indiana, USA
  3. 3 Divisoin of Hematology/Oncology, Indiana University School of Medicine, Indianapolis, Indiana, USA
  1. Correspondence to Dr Liang Cheng, Department of Pathology & Laboratory Medicine, Indiana University School of Medicine, Indianapolis, IN 46202, USA; liang_cheng{at}


Aims To describe a large tertiary care academic centre’s experience with patients who achieve a complete pathological response (ie, ypT0N0) following neoadjuvant chemotherapy (NAC) and radical cystectomy (RC) with emphasis on morphological features present in the RC and clinical outcome.

Methods 41 patients with ypT0N0 disease following transurethral resection of bladder tumour (TURBT), NAC and RC with available clinical follow-up information were analysed. Slides from all RCs were reviewed to confirm pathological stage and assess for morphological parameters (eg, foreign body giant cell reaction, dystrophic calcification, scar and fat necrosis).

Results With median follow-up of 32.8 months, the recurrence-free survival at 1 and 5 years was 97.4% and 93.5%, while the overall survival at 3 and 5 years was 94.2% and 88.6%, respectively. No patients died of urothelial carcinoma. Stage assigned at TURBT was 1 pTa (2%), 1 pT1 (2%), 38 pT2 (93%) and 1 pT3a (2%). 17 TURBTs demonstrated variant histology, with the majority of these being squamous (65%). The most common morphological features present at RC were scar (100%), foreign body giant cell reaction (80%), chronic inflammation within lamina propria (68%) and dystrophic calcifications (39%). Other morphological features were less common or absent.

Conclusion ypT0N0 disease at RC portends an excellent prognosis, regardless of stage or variant histology in the TURBT; scar, foreign body giant cell reaction, chronic inflammation and dystrophic calcifications are often present.

  • bladder
  • urothelial carcinoma
  • staging
  • histopathology
  • neoadjuvant chemotherapy
  • prognosis

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  • Handling editor Cheok Soon Lee.

  • Contributors MJM and LC are involved in conception and design of the paper. MJM and LC are responsible for data acquisition, data analysis and writing the article. All the authors (MJM, HZK, MPB, EB, NA, MOK, LC) read, edited and approved the final manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Ethics approval The study was approved by the Institutional Review Board of Indiana University-Purdue University Indianapolis.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.