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Angiomatosis of the breast: a clinicopathological and immunophenotypical characterisation of seven cases
  1. Paula S Ginter1,
  2. Patrick J McIntire1,
  3. Lina Irshaid2,
  4. Yi-Fang Liu1,
  5. Sandra J Shin3
  1. 1 Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, New York, USA
  2. 2 Department of Pathology, Yale School of Medicine, New Haven, CT, USA
  3. 3 Department of Pathology and Laboratory Medicine, Albany Medical College, Albany, New York, USA
  1. Correspondence to Dr Paula S Ginter, Department of Pathology and Laboratory Medicine, Weill Cornell Medical College, New York, NY 10065, USA; psg9003{at}


Aims Mammary angiomatosis is a rare, benign vascular lesion that morphologically mimics low-grade angiosarcoma (LGAS). To date, only occasional reports of this entity have been published, none of which included analysis by immunohistochemistry. The purpose of this study was to further characterise mammary angiomatosis by clinical, histological, and immunohistochemical means while emphasising distinguishing features from LGAS.

Methods Seven cases of primary mammary angiomatosis were evaluated. For one patient, a subsequent recurrence was also evaluated.

Results All patients were female with a median age at presentation of 51 years (range: 19–58 years). The most common clinical presentation was that of a palpable abnormality or mass (5/8) and the median primary tumour size was 3.1 cm (range: 2–9 cm). Of the six patients with follow-up, one developed a recurrence 6 years after initial presentation. Histologically, all cases were composed of variably sized ectatic, thin-walled vessels lined by flat normochromic endothelium diffusely infiltrating mammary stroma. Where present, lesional vessels infiltrated between and around terminal duct lobular units but not into individual intralobular stroma. Most cases (6/8) showed a combination of lymphatic-appearing and haemangiomatous-appearing vessels. Lymphatic-appearing vessels were D2-40 positive in all but one case. D2-40 was negative or weak in haemangiomatous-appearing vessels. All lesional vessels were CD31 positive. Ki-67 indices were <1% in all but one case (5%).

Conclusions Mammary angiomatosis is a rare vascular lesion that shares clinical, morphological and immunohistochemical features with LGAS; however, certain key traits make the distinction possible.

  • vascular tumours
  • ki-67
  • breast
  • angiomatosis

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  • Handling editor Dr Cheok Soon Lee.

  • Presented at Some findings in this manuscript were presented (in abstract form) at the 2017 United States and Canadian Academy of Pathology (USCAP) Annual Meeting in San Antonio, Texas on 8 March 2017.

  • Contributors PSG contributed to project concept, data collection and manuscript preparation. PJM contributed to data collection and manuscript preparation. LI and Y-FL contributed to data collection and reviewed the prepared manuscript. SJS contributed to the project concept, data collection and reviewed the prepared manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Not commissioned; externally peer reviewed.

  • Data availability statement All data relevant to the study are included in the article or uploaded as supplementary information.