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Multiple sclerosing pneumocytomas: a review
  1. Prodipto Pal1,2,
  2. Runjan Chetty1,2
  1. 1 Laboratory Medicine and Pathobiology, University of Toronto, Toronto, Ontario, Canada
  2. 2 Department of Pathology, University Health Network Laboratory Medicine Program, University of Toronto, Toronto, Ontario, Canada
  1. Correspondence to Dr Prodipto Pal, Pathology, Toronto General Hospital, Toronto, ON M5G 2C4, Canada; prodipto.pal{at}


Sclerosing pneumocytoma (SP) is a rare benign low-grade tumour of the lung, and typically presents as single discrete coin lesions on imaging. Multiple SP is an exceedingly rare entity and thus reported sparingly. We review the literature on multiple SP, their clinical presentations, histopathology, relevant differential diagnoses and molecular histogenesis of this entity. SP has a predilection for East Asian origin females who have never smoked. Patients are either asymptomatic or have symptoms such as cough, haemoptysis that may be persistent, chest pain if involving the pleura and presents as discrete coin lesion on chest X-ray. Histologically, they are papillary, solid, angiomatoid or sclerotic, or combinations of these four basic patterns. Multiple lesions have the same or slightly different histological patterns. They can be distributed in either lung, in any lobe and can even be bilateral. AKT-1 molecular pathways are pivotal in their molecular pathogenesis. In this review, we further propose a classification based on five types of distribution of multiple SP.

  • lung
  • histopathology
  • pulmonary pathology
  • surgical pathology

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  • Handling editor Dhirendra Govender.

  • Contributors Both authors contributed to this manuscript. PP and RC conceived the idea and both authors contributed equally to the design and writing of the manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Patient consent for publication Not required.

  • Provenance and peer review Commissioned; externally peer reviewed.