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Risk factors evaluation of post-transplant lymphoproliferative disorders after allogeneic haematopoietic stem cell transplantation with comparison between paediatric and adult
  1. Ding Bao Chen1,
  2. Xiao Yang Liu1,
  3. Fang Zhou Kong1,
  4. Qian Jiang2,
  5. Dan Hua Shen1
  1. 1 Pathology, Peking University People's Hospital, Beijing, China
  2. 2 Hematology, Peking University People's Hospital, Beijing, China
  1. Correspondence to Dr Ding Bao Chen, Pathology, Peking University People's Hospital, Beijing, China; cdingbao{at}


To describe the clincopathological features and evaluate risk factors of post-transplant lymphoproliferative disorder (PTLD) after allogeneic haematopoietic stem cell transplants (allo-HSCT), with comparison between paediatric and adult .

Clinicopathological features of 81 cases of PTLD after allo-HSCT were analysed by histopatholgy, immunohistochemistry and in situ hybridisatioin.

The cases included 58 males and 23 females with a median age of 26.7 years (range 6–55 years) and the PTLDs developed 1–60 months post-transplant (mean 5.9 months). The histological types indicated 10 cases of non-destructive PTLD, including 4 of plasmacytic hyperplasia, 5 of infectious mononucleosis and 1 of florid follicular hyperplasia. Fifty-six cases were polymorphic PTLD, and 15 were monomorphic PTLD, including thirteen of diffuse large B cell lymphoma, 1 of extranodal nasal type natural killer (NK)/T cell lymphoma and 1 of plasmablastic lymphoma. Foci and sheets of necrosis were observed in 31 cases. The infected ratio of Epstein-Barr virus (EBV) was 91.4%. Some cases were treated by reduction of immunosuppression, antiviral therapy, donor lymphocyte infusion or anti-CD20 monoclonal rituximab. Thirty-three cases died. Compared with that of adult, overall survival of paediatric recipient may be better.

The first half year after allo-HSCT is very important for the development of PTLD. Type of PTLD, EBV infection and graft-versus-host disease are risk factors. The prognosis of PTLD is poor, and PTLD after allo-HSCT exhibits some features different from that after solid organ transplantation and some differences existing between adult and paediatric recipients.

  • immunohistochemistry
  • lymphoma
  • epstein-barr virus infections
  • leukemia
  • transplantation

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  • Handling editor Mary Frances McMullin.

  • Contributors All authors (DBC, XYL, FZK, QJ and DHS) were involved in the conception and/or design of the study. DBC and XYL participated in the collection or generation of the study data. FZK contributed with laboratory analysis, reagents and tools. XYL was lead statistician of the project, reviewed and provided input for the reporting of the results. DBC led the design and initiation of the project and served as a project supervisor throughout. DBC, XYL, FZK, QJ and DHS were involved in the analyses and/or interpretation of the data. All authors read, reviewed and approved the present manuscript.

  • Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

  • Competing interests None declared.

  • Provenance and peer review Not commissioned; externally peer reviewed.