Footnotes

• Handling editor Mary Frances McMullin.

• Contributors SEL, DO and SM performed laboratory studies. CLB and EV provided clinical oversight. All authors contributed to manuscript preparation and approved the submitted version.

• Funding The authors have not declared a specific grant for this research from any funding agency in the public, commercial or not-for-profit sectors.

• Competing interests None declared.

• Provenance and peer review Not commissioned; externally peer reviewed.